ArticleOptics express2011
Diffuse optical monitoring of repeated cerebral ischemia in mice.
Article in Optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 77 citations in OpenAlex.
- Near-infrared diffuse correlation spectroscopy tracks changes in oxygen delivery and utilization during exercise with and without isolated arterial compression.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia.Arthritis research & therapy · 2012Trial
- Article
- Functionalized biomimetic nanoparticles are delivered from the nose to the brain for the synergistic targeted treatment of cerebral ischemia/reperfusion injury.Regenerative biomaterials · 2025Article
- Diffuse correlation tomography: a technique to characterize tissue blood flow abnormalities in benign and malignant breast lesions.Biomedical optics express · 2024Article
- Quantification of blood flow index in diffuse correlation spectroscopy using a robust deep learning method.Journal of biomedical optics · 2024Article
- Neuroprotective effect of the RNS60 in a mouse model of transient focal cerebral ischemia.PloS one · 2024Article
- Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography.Journal of biomedical optics · 2023Article
- Depth-sensitive diffuse speckle contrast topography for high-density mapping of cerebral blood flow in rodents.Neurophotonics · 2023Article
- A Wearable Fiber-Free Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Freely Behaving Mice.IEEE transactions on bio-medical engineering · 2023Article
- hsa-miR-518-5p/hsa-miR-3135b Regulates the REL/SOD2 Pathway in Ischemic Cerebral Infarction.Frontiers in neurology · 2022Article
- The Quantitative Associations Between Near Infrared Spectroscopic Cerebrovascular Metrics and Cerebral Blood Flow: A Scoping Review of the Human and Animal Literature.Frontiers in physiology · 2022Article
- Performance assessment of laser sources for time-domain diffuse correlation spectroscopy.Biomedical optics express · 2021Article
- Extraction of tissue optical property and blood flow from speckle contrast diffuse correlation tomography (scDCT) measurements.Biomedical optics express · 2021Article
- Collimating micro-lens fiber array for noncontact near-infrared diffuse correlation tomography.Biomedical optics express · 2021Article
- Resuscitating the Globally Ischemic Brain: TTM and Beyond.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Noninvasive noncontact speckle contrast diffuse correlation tomography of cerebral blood flow in rats.NeuroImage · 2019Article
- Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near-infrared diffuse correlation spectroscopy.The Journal of physiology · 2019Article
- Portable Near-Infrared Technologies and Devices for Noninvasive Assessment of Tissue Hemodynamics.Journal of healthcare engineering · 2019Review
- Approaches to denoise the diffuse optical signals for tissue blood flow measurement.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Occlusions of bilateral common carotid arteries (bi-CCA) in mice are popular models for the investigation of transient forebrain ischemia. Currently available technologies for assessing cerebral blood flow (CBF) and oxygenation in ischemic mice have limitations. This study tests a novel near-infrared diffuse correlation spectroscopy (DCS) flow-oximeter for monitoring both CBF and cerebral oxygenation in mice undergoing repeated transient forebrain ischemia. Concurrent flow measurements in a mouse brain were first conducted for validation purposes; DCS measurement was found highly correlated with laser Doppler measurement (R2 = 0.94) and less susceptible to motion artifacts. With unique designs in experimental protocols and fiber-optic probes, we have demonstrated high sensitivities of DCS flow-oximeter in detecting the regional heterogeneity of CBF responses in different hemispheres and global changes of both CBF and cerebral oxygenation across two hemispheres in mice undergoing repeated 2-minute bi-CCA occlusions over 5 days. More than 75% CBF reductions were found during bi-CCA occlusions in mice, which may be considered as a threshold to determine a successful bi-CCA occlusion. With the progress of repeated 2-minute bi-CCA occlusions over days, a longitudinal decline in the magnitudes of CBF reduction was observed, indicating the brain adaptation to cerebral ischemia through the repeated preconditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.