ArticleMolecules (Basel, Switzerland)2011
Synthesis and pharmacological activity of diterpenylnaphthoquinone derivatives.
Article in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Uncovering the gastroprotective properties of araucaria brown propolis and its active compound, abietic acid.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Synthesis, Antiviral and Cytotoxic Activity of Novel Terpenyl Hybrid Molecules Prepared by Click Chemistry.Molecules (Basel, Switzerland) · 2018Article
- Synthesis and Biological Evaluation of Lipophilic 1,4-Naphthoquinone Derivatives against Human Cancer Cell Lines.Molecules (Basel, Switzerland) · 2015Article
- Diterpenylquinone hybrids: synthesis and assessment of gastroprotective mechanisms of action in human cells.Molecules (Basel, Switzerland) · 2013Article
- Dimeric labdane diterpenes: synthesis and antiproliferative effects.Molecules (Basel, Switzerland) · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
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