ArticleHuman heredity2011
Genetic factors influence serological measures of common infections.
Article in Human heredity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.Genome medicine · 2018Trial
- Atypical acuteFujita medical journal · 2026Article
- Immunoglobulin allotypes andJournal of Alzheimer's disease : JAD · 2026Article
- Polygenic risk score and phenome-wide association study of the Epstein-Barr virus antibody response.Frontiers in genetics · 2026Article
- Genetic estimates and genome-wide association studies of antibody response in Tanzanian dairy cattle.Frontiers in genetics · 2025Article
- Article
- Genetic and psychosocial influence on the association between early childhood infections and later psychiatric disorders.Acta psychiatrica Scandinavica · 2022Article
- Article
- Human genomics of the humoral immune response against polyomaviruses.Virus evolution · 2021Article
- The Chinese Herbal Prescription JieZe-1 Inhibits Membrane Fusion and the Toll-like Receptor Signaling Pathway in a Genital Herpes Mouse Model.Frontiers in pharmacology · 2021Article
- Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility.PloS one · 2021Article
- EBNA-1 titer gradient in families with multiple sclerosis indicates a genetic contribution.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Schizophrenia and Influenza at the Centenary of the 1918-1919 Spanish Influenza Pandemic: Mechanisms of Psychosis Risk.Frontiers in psychiatry · 2020Review
- Serum anti-World journal of gastroenterology · 2018Article
- Article
- Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle.BMC genomics · 2018Article
- Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot.Global health, epidemiology and genomics · 2017Article
- Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.American journal of human genetics · 2015Article
- Genome-wide genetic investigation of serological measures of common infections.European journal of human genetics : EJHG · 2015Article
- Helicobacter pylori Antibody Titer and Gastric Cancer Screening.Disease markers · 2015Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
aimsAntibodies against infectious pathogens provide information on past or present exposure to infectious agents. While host genetic factors are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable.
methodsIgG antibodies to Chlamydophila pneumoniae, Helicobacter pylori, Toxoplasma gondii, adenovirus 36 (Ad36), hepatitis A virus, influenza A and B, cytomegalovirus, Epstein-Barr virus, herpes simplex virus (HSV)-1 and -2, human herpesvirus-6, and varicella zoster virus were determined for 1,227 Mexican Americans. Both quantitative and dichotomous (seropositive/seronegative) traits were analyzed. Influences of genetic and shared environmental factors were estimated using variance components pedigree analysis, and sharing of underlying genetic factors among traits was investigated using bivariate analyses.
resultsSerological phenotypes were significantly heritable for most pathogens (h(2) = 0.17-0.39), except for Ad36 and HSV-2. Shared environment was significant for several pathogens (c(2) = 0.10-0.32). The underlying genetic etiology appears to be largely different for most pathogens.
conclusionsOur results demonstrate, for the first time for many of these pathogens, that individual genetic differences of the human host contribute substantially to antibody levels to many common infectious agents, providing impetus for the identification of underlying genetic variants, which may be of clinical importance.
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