ArticleThe American journal of pathology2011
FosB regulates stretch-induced expression of extracellular matrix proteins in smooth muscle.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
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- Single-cell transcriptomics of vascularized human brain organoids decipher lineage-specific stress adaptation in fetal hypoxia-reoxygenation injury.Theranostics · 2025Article
- Investigation of the impact of bromodomain inhibition on cytoskeleton stability and contraction.Cell communication and signaling : CCS · 2024Article
- Investigation of the impact of bromodomain inhibition on cytoskeleton stability and contraction.bioRxiv : the preprint server for biology · 2023Article
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- Temporomandibular Disorders Slow Down the Regeneration Process of Masticatory Muscles: Transcriptomic Analysis.Medicina (Kaunas, Lithuania) · 2021Article
- CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.Nature neuroscience · 2021Article
- Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology.Nature communications · 2020Article
- Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function.JCI insight · 2019Article
- MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.Journal of translational medicine · 2019Article
- The PPI network analysis of mRNA expression profile of uterus from primary dysmenorrheal rats.Scientific reports · 2018Article
- Targeting of CCN2 suppresses tumor progression and improves chemo-sensitivity in urothelial bladder cancer.Oncotarget · 2017Article
- Simulated physiological stretch increases expression of extracellular matrix proteins in human bladder smooth muscle cells via integrin α4/αv-FAK-ERK1/2 signaling pathway.World journal of urology · 2017Article
- SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy.BMB reports · 2016Article
- Dynamic reciprocity in cell-scaffold interactions.Advanced drug delivery reviews · 2015Review
- Article
- Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy.American journal of physiology. Cell physiology · 2014Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Fibroproliferative remodeling in smooth muscle-rich hollow organs is associated with aberrant extracellular matrix (ECM) production. Although mechanical stimuli regulate ECM protein expression, the transcriptional mediators of this process remain poorly defined. Previously, we implicated AP-1 as a mediator of smooth muscle cell (SMC) mechanotransduction; however, its role in stretch-induced ECM regulation has not been explored. Herein, we identify a novel role for the AP-1 subunit FosB in stretch-induced ECM expression in SMCs. The DNA-binding activity of AP-1 increased after stretch stimulation of SMCs in vitro. In contrast to c-Jun and c-fos, which are also activated by the SMC mitogen platelet-derived growth factor, FosB was only activated by stretch. FosB silencing attenuated the expression of the profibrotic factors tenascin C (TNC) and connective tissue growth factor (CTGF), whereas forced expression of Jun~FosB stimulated TNC and CTGF promoter activity. Chromatin immunoprecipitation revealed enrichment of AP-1 at the TNC and CTGF promoters. Bladder distension in vivo enhanced nuclear localization of c-jun and FosB. Finally, the distension-induced expression of TNC and CTGF in the detrusor smooth muscle of bladders from wild-type mice was significantly attenuated in FosB-null mice. Together, these findings identify FosB as a mechanosensitive regulator of ECM production in smooth muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.