ArticleObesity (Silver Spring, Md.)2012
Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain.
Article in Obesity (Silver Spring, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Harnessing adiponectin for sepsis: current knowledge, clinical insights and future therapies.Critical care (London, England) · 2025Review
- The Biological Changes of Synaptic Plasticity in the Pathological Process of Sepsis-associated Encephalopathy.Current neuropharmacology · 2025Review
- Immune regulation and organ damage link adiponectin to sepsis.Frontiers in immunology · 2024Review
- Adipose tissue: a neglected organ in the response to severe trauma?Cellular and molecular life sciences : CMLS · 2022Review
- [Value of cerebral hypoxic-ischemic injury markers in the early diagnosis of sepsis associated encephalopathy in burn patients with sepsis].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Article
- Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats.Animal models and experimental medicine · 2021Article
- Gold nanoparticles reduce inflammation in cerebral microvessels of mice with sepsis.Journal of nanobiotechnology · 2021Article
- Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis.Frontiers in aging neuroscience · 2021Article
- Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.Inflammation · 2019Article
- Potential therapeutic action of nitrite in sickle cell disease.Redox biology · 2017Article
- Blood-Brain Barriers in Obesity.The AAPS journal · 2017Review
- Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.Journal of immunology research · 2017Article
- Relationships between adiponectin and matrix metalloproteinase-9 (MMP-9) serum levels and postoperative cognitive dysfunction in elderly patients after general anesthesia.Aging clinical and experimental research · 2016Article
- Endothelial Activation and Blood-Brain Barrier Injury as Risk Factors for Delirium in Critically Ill Patients.Critical care medicine · 2016Article
- Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice.Journal of inflammation research · 2016Article
- Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.Obesity (Silver Spring, Md.) · 2015Article
- Differential effects of leptin and adiponectin in endothelial angiogenesis.Journal of diabetes research · 2015Review
- SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.Journal of leukocyte biology · 2014Article
- Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation, and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Obesity increases circulating cell-endothelial cell interactions; an early marker of inflammation in laboratory model of sepsis, but little is known about the effect of different adipokines. Adiponectin is an anti-inflammatory adipokine secreted by adipocytes. Adiponectin deficiency is implicated in exaggerated proinflammatory phenotype in both obesity and sepsis via increased proinflammatory cytokine expression. However the effect of adiponectin deficiency on circulating cell-endothelial cell interactions in polymicrobial sepsis is unknown. Furthermore although brain dysfunction in septic patients is a known predictor of death, the pathophysiology involved is unknown. In the current study, we examined the effects of adiponectin deficiency on leukocyte (LA) and platelet adhesion (PA) in cerebral microcirculation of septic mice. Adiponectin deficient (Adipoq(-/-): Adko) and background strain C57Bl/6 (wild type (WT)) mice were used. Sepsis was induced using cecal ligation and puncture (CLP). We studied LA and PA in the cerebral microcirculation using intravital fluorescent video microscopy (IVM), blood brain barrier (BBB) dysfunction using Evans Blue (EB) leakage method and E-selectin expression using dual radiolabeling technique in different WT and Adko mice with CLP. Adiponectin deficiency significantly exaggerated LA (WT-CLP:201 ± 17; Adko-CLP: ± 53 cells/mm(2); P < 0.05) and PA (WT-CLP:125 ± 17; Adko-CLP:188 ± 20 cells/mm(2); P < 0.05) in cerebral microcirculation, EB leakage (WT-CLP:10 ± 3.7; Adko-CLP:24 ± 4.3 ng/g × µl plasma; P < 0.05) and E-selectin expression (WT-CLP:0.06 ± 0.11; Adko-CLP:0.44 ± 0.053 ng/g; P < 0.05) in the brain tissue of the mice with CLP. Furthermore, E-selectin monoclonal antibody (mAb) treatment attenuated cell adhesion and BBB dysfunction of Adko-CLP mice. Adiponectin deficiency is associated with exaggerated leukocyte and PA in cerebral microcirculation of mice with CLP via modulation of E-selectin expression.
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