ReviewCells, tissues, organs2012
How blood vessel networks are made and measured.
Review in Cells, tissues, organs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases.American heart journal plus : cardiology research and practice · 2025Review
- Under pressure: integrated endothelial cell response to hydrostatic and shear stresses.Vascular biology (Bristol, England) · 2025Article
- Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach.Breast cancer research : BCR · 2023Article
- Article
- Revealing the uterine blood vessel network via virtual pathology.Reproduction & fertility · 2023Article
- Morphometric analysis of tumor microvessels for detection of hepatocellular carcinoma using contrast-free ultrasound imaging: A feasibility study.Frontiers in oncology · 2023Article
- Rab35 governs apicobasal polarity through regulation of actin dynamics during sprouting angiogenesis.Nature communications · 2022Article
- Trafficking in blood vessel development.Angiogenesis · 2022Review
- Critical Role of Neuronal Vps35 in Blood Vessel Branching and Maturation in Developing Mouse Brain.Biomedicines · 2022Article
- The Important Role of Endothelium and Extracellular Vesicles in the Cellular Mechanism of Aortic Aneurysm Formation.International journal of molecular sciences · 2021Review
- Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking.Angiogenesis · 2021Article
- SMAD6 transduces endothelial cell flow responses required for blood vessel homeostasis.Angiogenesis · 2021Article
- Spheroid Coculture of Human Gingiva-Derived Progenitor Cells With Endothelial Cells in Modified Platelet Lysate Hydrogels.Frontiers in bioengineering and biotechnology · 2021Article
- Understanding angiogenesis and the role of angiogenic growth factors in the vascularisation of engineered tissues.Molecular biology reports · 2021Review
- Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex.The Journal of clinical investigation · 2020Article
- Biological network growth in complex environments: A computational framework.PLoS computational biology · 2020Article
- Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (International journal of molecular sciences · 2020Article
- Tortuous Microvessels Contribute to Wound Healing via Sprouting Angiogenesis.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Development and Validation of a Histological Method to Measure Microvessel Density in Whole-Slide Images of Cancer Tissue.PloS one · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Tissue and organ viability depends on the proper systemic distribution of cells, nutrients, and oxygen through blood vessel networks. These networks arise in part via angiogenic sprouting. Vessel sprouting involves the precise coordination of several endothelial cell processes including cell-cell communication, cell migration, and proliferation. In this review, we discuss zebrafish and mammalian models of blood vessel sprouting and the quantification methods used to assess vessel sprouting and network formation in these models. We also review the mechanisms involved in angiogenic sprouting, and we propose that the process consists of distinct stages. Sprout initiation involves endothelial cell interactions with neighboring cells and the environment to establish a specialized tip cell responsible for leading the emerging sprout. Furthermore, local sprout guidance cues that spatially regulate this outward migration are discussed. We also examine subsequent events, such as sprout fusion and lumenization, that lead to maturation of a nascent sprout into a patent blood vessel.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.