Evidence map›Paper›PMID 21996576›Full record

ArticleCells, tissues, organs2012

Methods of cell purification: a critical juncture for laboratory research and translational science.

Peter J Amos, Esra Cagavi Bozkulak, Yibing Qyang

Open access · bronzeAbstract read
In one paragraph

Article in Cells, tissues, organs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Frontiers in immunology · 2022
    Article
  6. Article
  7. Ultrasound-based cell sorting with microbubbles: A feasibility study.The Journal of the Acoustical Society of America · 2018
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Peter J AmosSection of Cardiology, Department of Internal Medicine, Yale Stem Cell Center, Yale School of Medicine, Yale University, New Haven, Conn. 06519, USA.
Esra Cagavi Bozkulak
Yibing Qyang
Yale Cancer Center · USYale University · US

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Vascular Training GrantT32HL007950 · NHLBI · YALE UNIVERSITY · PI JEFFREY R. BENDER, Daniel Greif · 2000 to 2026
$9.6M
Derivation of Heart Cells from Human Embryonic and Induced Pluripotent Stem CellsK02HL101990 · NHLBI · YALE UNIVERSITY · PI QYANG, YIBING · 2010 to 2014
$489k
NCRR NIH HHS UL1 RR024139NHLBI NIH HHS 1K02HL101990-01NHLBI NIH HHS 5T32 HL007950NHLBI NIH HHS K02 HL101990NHLBI NIH HHS T32 HL007950
6 · The paper itself

Abstract

Research in cell biology and the development of translational technologies are driven by competition, public expectations, and regulatory oversight, putting these fields at a critical juncture. Success in these fields is quickly becoming dependent on the ability of researchers to identify and isolate specific cell populations from heterogeneous mixtures accurately and efficiently. Many methods for cell purification have been developed, and each has advantages and disadvantages that must be considered in light of the intended application. Current cell separation strategies make use of surface proteins, genetic expression, and physics to isolate specific cells by phenotypic traits. Cell purification is also dependent on the cellular reagents available for use and the intended application, as these factors may preclude certain mechanisms used in the processes of labeling and sorting cells.

Indexed as

AnimalsCell SeparationFlow CytometryHumansRecombination, GeneticTranslational Research, BiomedicalViruses

Identifiers

PMID21996576
PMCPMC3257814
OpenAlexW2073821411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.