Trial reportJournal of the American College of Surgeons2011
A stepwise approach and early clinical experience in peroral endoscopic myotomy for the treatment of achalasia and esophageal motility disorders.
Trial report in Journal of the American College of Surgeons, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia: A Randomized, Controlled Trial
Comparison of Peroral Endoscopic Myotomy (POEM) With Laparoscopic Heller Myotomy (LHM) for Treatment of Achalasia, a Retrospective Multicenter Study
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- ACG Clinical Guidelines: Diagnosis and Management of Achalasia.The American journal of gastroenterology · 2020Guideline
- Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: a systematic review and meta-analysis.Surgical endoscopy · 2015Pooled it
- Peroral endoscopic myotomyWorld journal of gastroenterology · 2022Trial
- Peroral endoscopic myotomy for idiopathic achalasia: randomized comparison of water-jet assisted versus conventional dissection technique.Surgical endoscopy · 2014Trial
- Water-jetWorld journal of gastrointestinal endoscopy · 2022Article
- Changes in Distensibility Index During an Incremental POEM Myotomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
- Peroral endoscopic myotomy for management of gastrointestinal motility disorder.World journal of clinical cases · 2020Review
- Per-oral endoscopic myotomy and gastroesophageal reflux: Where do we stand after a decade of "POETRY"?Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Review
- Consensus on the digestive endoscopic tunnel technique.World journal of gastroenterology · 2019Article
- Bridging the Gap between Advancements in the Evolution of Diagnosis and Treatment towards Better Outcomes in Achalasia.BioMed research international · 2019Review
- Per oral endoscopic myotomy vs. laparoscopic Heller myotomy, does gastric extension length matter?Surgical endoscopy · 2018Article
- Clinical outcomes five years after POEM for treatment of primary esophageal motility disorders.Surgical endoscopy · 2018Article
- Comprehensive Analysis of Adverse Events Associated With Per Oral Endoscopic Myotomy in 1826 Patients: An International Multicenter Study.The American journal of gastroenterology · 2017Article
- The impact of flexible endoscopy in esophageal surgery.Journal of thoracic disease · 2017Review
- Outcomes in patients with over 1-year follow-up after peroral endoscopic myotomy (POEM).Surgical endoscopy · 2017Article
- Impact of prior interventions on outcomes during per oral endoscopic myotomy.Surgical endoscopy · 2017Article
- Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center.World journal of gastroenterology · 2017Article
- The current state of per oral endoscopic myotomy for achalasia.Journal of visualized surgery · 2017Review
- Peroral endoscopic myotomy: procedural complications and pain management for the perioperative clinician.Medical devices (Auckland, N.Z.) · 2017Article
- A Matched Comparison of Per Oral Endoscopic Myotomy to Laparoscopic Heller Myotomy in the Treatment of Achalasia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeroral endoscopic myotomy (POEM) has recently been described in humans as a treatment for achalasia. This concept has evolved from developments in natural orifice translumenal endoscopic surgery (NOTES) and has the potential to become an important therapeutic option. We describe our approach as well as our initial clinical experience as part of an ongoing study treating achalasia patients with POEM. STUDY
designFive patients (mean age 64 ± 11 years) with esophageal motility disorders were enrolled in an IRB-approved study and underwent POEM. This completely endoscopic procedure involved a midesophageal mucosal incision, a submucosal tunnel onto the gastric cardia, and selective division of the circular and sling fibers at the lower esophageal sphincter. The mucosal entry was closed by conventional hemostatic clips. All patients had postoperative esophagograms before discharge and initial clinical follow-up 2 weeks postoperatively.
resultsAll (5 of 5) patients successfully underwent POEM treatment, and the myotomy had a median length of 7 cm (range 6 to 12 cm). After the procedure, smooth passage of the endoscope through the gastroesophageal junction was observed in all patients. Operative time ranged from 120 to 240 minutes. No leaks were detected in the swallow studies and mean length of stay was 1.2 ± 0.4 days. No clinical complications were observed, and at the initial follow-up, all patients reported dysphagia relief without reflux symptoms.
conclusionsOur initial experience with the POEM procedure demonstrates its operative safety, and early clinical results have shown good results. Although further evaluation and long-term data are mandatory, POEM could become the treatment of choice for symptomatic achalasia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.