ArticleEpigenetics & chromatin2011
Proliferating cell nuclear antigen is required for loading of the SMCX/KMD5C histone demethylase onto chromatin.
Article in Epigenetics & chromatin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Post-Translational Modifications of PCNA: Guiding for the Best DNA Damage Tolerance Choice.Journal of fungi (Basel, Switzerland) · 2022Review
- Functions and Interactions of Mammalian KDM5 Demethylases.Frontiers in genetics · 2022Review
- The genetic architecture of DNA replication timing in human pluripotent stem cells.Nature communications · 2021Observational
- KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance.Biology open · 2021Article
- Human PCNA Structure, Function and Interactions.Biomolecules · 2020Review
- Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.The Journal of clinical investigation · 2015Article
- H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing.Nucleic acids research · 2015Article
- Chromatin replication and epigenome maintenance.Nature reviews. Molecular cell biology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHistone methylation is regulated by a large number of histone methyltransferases and demethylases. The recently discovered SMCX/KMD5C demethylase has been shown to remove methyl residues from lysine 4 of histone H3 (H3K4), and constitutes an important component of the regulatory element-1-silencing transcription factor (REST) protein complex. However, little is known about the cellular mechanisms that control SMCX activity and intracellular trafficking.
resultsIn this study, we found that small interfering RNA-mediated knockdown of proliferating cell nuclear antigen (PCNA) resulted in the reduction of the chromatin-bound SMCX fraction. We identified a PCNA-interaction protein motif (PIP box) in the SMCX protein. Using site-directed mutagenesis, we found that the amino acids of the SMCX PIP box are involved in the association of SMCX with PCNA and its interaction with chromatin.
conclusionsOur data indicate that the intracellular trafficking of SMCX is controlled by its association with PCNA.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.