ArticleSchizophrenia research2011
Relationship of neurocognitive deficits to diagnosis and symptoms across affective and non-affective psychoses.
Article in Schizophrenia research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Postmortem evidence of decreased brain pH in major depressive disorder: a systematic review and meta-analysis.Translational psychiatry · 2024Pooled it
- Pooled it
- Emotion and Theory of Mind in Schizophrenia-Investigating the Role of the Cerebellum.Cerebellum (London, England) · 2016Pooled it
- Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia.Translational psychiatry · 2024Trial
- Antipsychotic dose is not associated with cognitive function in patients with schizophrenia aged under 40: a cross-sectional observational study with retrospective dose estimation.BMC psychiatry · 2026Observational
- Towards Enhancing Drug Development Methodology to Treat Cognitive Impairment Associated With Schizophrenia and Other Neuropsychiatric Conditions: Insights From 2 Decades of Clinical Trials.Schizophrenia bulletin · 2025Review
- Comparison of cognitive performance in first-episode drug-naïve schizophrenia, bipolar II disorder, and major depressive disorder patients after treatment.BMC psychiatry · 2024Article
- A genome-wide association study of the longitudinal course of executive functions.Translational psychiatry · 2021Article
- Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.Scientific reports · 2021Article
- Article
- Cognitive and clinical predictors of community functioning across the psychoses.PsyCh journal · 2020Article
- Procedural memory consolidation after a night of sleep in bipolar disorder with psychotic features.Schizophrenia research · 2019Article
- The Relationship Between Cognitive Dysfunction and Symptom Dimensions Across Schizophrenia, Bipolar Disorder, and Major Depressive Disorder.Frontiers in psychiatry · 2019Article
- Cognitive Deficits in Psychotic Disorders: A Lifespan Perspective.Neuropsychology review · 2018Review
- Examining cognition across the bipolar/schizophrenia diagnostic spectrum.Journal of psychiatry & neuroscience : JPN · 2018Article
- Aberrant cerebellar connectivity in bipolar disorder with psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls.Schizophrenia bulletin · 2017Article
- Performance of Bipolar Disorder Patients in Attention Testing: Comparison with Normal Controls and Among Manic, Depressive, and Euthymic Phases.The Psychiatric quarterly · 2017Article
- Role of calcium channels in bipolar disorder.Current psychopharmacology · 2017Article
- Reward Learning, Neurocognition, Social Cognition, and Symptomatology in Psychosis.Frontiers in psychiatry · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
introductionNeurocognitive dysfunction is believed to be a core feature of schizophrenia and is increasingly recognized as a common symptom dimension in bipolar disorder. Despite a copious literature on neurocognition in these disorders, the relationship amongst neurocognition, symptoms, and diagnosis remains unclear. We examined neurocognitive functioning in a cross-diagnostic sample of patients with psychotic disorders. Based on previous findings, it was hypothesized that neurocognitive functioning would be impaired in all three patient groups, and that groups would be similarly impaired on all neuropsychological measures. Additionally, we predicted that negative symptoms but not positive, general, or mood symptoms, would be associated with neurocognitive functioning.
methodNeurocognitive functioning and symptoms were assessed in participants with schizophrenia (n=25), schizoaffective disorder (n=29), or bipolar disorder with psychosis (n=31), and in healthy controls (n=20).
resultsNeurocognitive functioning was significantly impaired in all patient groups, and groups did not differ by diagnosis on most measures. A series of linear regressions revealed that negative symptoms (but no other clinical symptom) predicted poorer executive functioning across groups. Diagnosis was not a significant predictor of any neurocognitive variable. DISCUSSION: Neurocognitive deficits were pronounced in this cross-diagnostic sample of patients with psychotic disorders, and did not differ by diagnosis. Neurocognitive dysfunction may represent a symptom dimension that spans diagnostic categories, and may reflect shared pathogenic processes. As neurocognitive dysfunction is among the strongest predictors of outcome in patients, efforts to treat these deficits, which have shown promise in schizophrenia, should be extended to all patients with psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.