ArticleImmunotherapy2011
You, me and Foxp3: immune regulation for two.
Article in Immunotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Autofluorescence contributes to false-positive intracellular Foxp3 staining in macrophages: a lesson learned from flow cytometry.Journal of immunological methods · 2012Article
Corrections and comments
- Comment on
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Forkhead Box P3 (Foxp3) is a lineage-specific transcription factor that controls the differentiation of CD4(+) regulatory T cells. The expression of Foxp3 in regulatory T cells is crucial for the upregulation of immunosuppressive effector molecules, whereby Foxp3 disruption leads to the breakdown of immune tolerance and the development of autoimmune disease. The present study reveals how CD11b(+) F4/80(+) macrophages also express Foxp3; it is not solely restricted to T cells in the immune system. The expression of Foxp3 in CD11b(+) F4/80(+) macrophages endows them with immunosuppressive ability. Foxp3(+) macrophages were subjected to global gene expression and proteomic analyses to reveal their unique profile, demonstrating how the mode by which Foxp3(+) macrophages exert their function involves the upregulation of immunoregulatory pathways. This finding indicates that Foxp3 is more widely expressed in the immune cells than previously thought.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.