ArticleParticle and fibre toxicology2011
Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms.
Article in Particle and fibre toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 115 citations in OpenAlex.
- The Role and Phagocytic Mechanisms of Alveolar Macrophages in Inflammatory Responses Induced by Diesel Exhaust Particles.Environmental science & technology · 2025Article
- Human Primary Monocytes as a Model for in vitro Immunotoxicity Testing: Evaluation of the Regulatory Properties of TiOInternational journal of nanomedicine · 2025Article
- Osteoblasts-derived exosomes as potential novel communicators in particle-induced periprosthetic osteolysis.Materials today. Bio · 2024Article
- Titanium nanoparticles released from orthopedic implants induce muscle fibrosis via activation of SNAI2.Journal of nanobiotechnology · 2024Article
- Reproductive toxicity perspectives of nanoparticles: an update.Toxicology research · 2024Review
- In Vitro and In Vivo Models for Evaluating the Oral Toxicity of Nanomedicines.Nanomaterials (Basel, Switzerland) · 2020Review
- [Influence of oxidative/antioxidative biomarkers and inflammatory cytokines on rats after sub-acute orally administration of titanium dioxide nanoparticles].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Evaluation of the NLRP3 Inflammasome Activating Effects of a Large Panel of TiONanomaterials (Basel, Switzerland) · 2020Article
- Mechanoregulation of titanium dioxide nanoparticles in cancer therapy.Materials science & engineering. C, Materials for biological applications · 2020Review
- Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages.Mediators of inflammation · 2020Article
- Wear particles induce a new macrophage phenotype with the potential to accelerate material corrosion within total hip replacement interfaces.Acta biomaterialia · 2020Article
- Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease.Journal of immunotoxicology · 2019Review
- Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment.Nanotheranostics · 2019Review
- Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the CaParticle and fibre toxicology · 2018Article
- Probing Cellular Processes Using Engineered Nanoparticles.Bioconjugate chemistry · 2018Review
- An updated review of the genotoxicity of respirable crystalline silica.Particle and fibre toxicology · 2018Review
- TiORedox biology · 2018Article
- Effect of Engineered Nanoparticles on Exopolymeric Substances Release from Marine Phytoplankton.Nanoscale research letters · 2017Article
- Mechanism of N-acetyl-cysteine inhibition on the cytotoxicity induced by titanium dioxide nanoparticles in JB6 cells transfected with activator protein-1.Experimental and therapeutic medicine · 2017Article
- Cellular Response to Titanium Dioxide Nanoparticles in Intestinal Epithelial Caco-2 Cells is Dependent on Endocytosis-Associated Structures and Mediated by EGFR.Nanomaterials (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inhalation of (nano)particles may lead to pulmonary inflammation. However, the precise mechanisms of particle uptake and generation of inflammatory mediators by alveolar macrophages (AM) are still poorly understood. The aim of this study was to investigate the interactions between particles and AM and their associated pro-inflammatory effects in relation to particle size and physico-chemical properties.NR8383 rat lung AM were treated with ultrafine (uf), fine (f) TiO2 or fine crystalline silica (DQ12 quartz). Physico-chemical particle properties were investigated by transmission electron microscopy, elemental analysis and thermogravimetry. Aggregation and agglomeration tendency of the particles were determined in assay-specific suspensions by means of dynamic light scattering.All three particle types were rapidly taken up by AM. DQ12 and ufTiO2 , but not fTiO2 , caused increased extracellular reactive oxygen species (ROS), heme oxygenase 1 (HO-1) mRNA expression and tumor necrosis factor (TNF)-α release. Inducible nitric oxide synthase (iNOS) mRNA expression was increased most strongly by ufTiO2 , while DQ12 exclusively triggered interleukin (IL) 1β release. However, oscillations of intracellular calcium concentration and increased intracellular ROS were observed with all three samples. Uptake inhibition experiments with cytochalasin D, chlorpromazine and a Fcγ receptor II (FcγRII) antibody revealed that the endocytosis of fTiO2 by the macrophages involves actin-dependent phagocytosis and macropinocytosis as well as clathrin-coated pit formation, whereas the uptake of ufTiO2 was dominated by FcγIIR. The uptake of DQ12 was found to be significantly reduced by all three inhibitors. Our findings suggest that the contrasting AM responses to fTiO2 , ufTiO2 and DQ12 relate to differences in the involvement of specific uptake mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.