ArticleMicrobial cell factories2011
Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts.
Article in Microbial cell factories, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Genome-wide association analysis reveals specialization to hosts and niches in multiple species of the Lactobacillaceae.The ISME journal · 2026Article
- Determination of Technological Properties and CRISPR Profiles ofMicroorganisms · 2024Article
- Probiotics, their action modality and the use of multi-omics in metamorphosis of commensal microbiota into target-based probiotics.Frontiers in nutrition · 2022Review
- Metagenomic analysis reveals distinct patterns of gut lactobacillus prevalence, abundance, and geographical variation in health and disease.Gut microbes · 2020Article
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- Full-repertoire comparison of the microscopic objects composing the human gut microbiome with sequenced and cultured communities.Journal of microbiology (Seoul, Korea) · 2020Article
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- Comparative Genomics Analysis ofGenes · 2020Article
- The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response.Scientific reports · 2019Article
- Use of Lactic Acid Bacteria to Reduce Methane Production in Ruminants, a Critical Review.Frontiers in microbiology · 2019Review
- Comparative Genomics ofFrontiers in microbiology · 2018Article
- Phylogenomics and comparative genomics ofMicrobial genomics · 2017Article
- Novel Molecular Insights about Lactobacillar Sortase-Dependent Piliation.International journal of molecular sciences · 2017Review
- Gut Microbial Diversity Assessment of Indian Type-2-Diabetics Reveals Alterations in Eubacteria, Archaea, and Eukaryotes.Frontiers in microbiology · 2017Article
- An in silico pan-genomic probe for the molecular traits behind Lactobacillus ruminis gut autochthony.PloS one · 2017Article
- A Comparative Characterization of Different Host-sourcedFrontiers in microbiology · 2017Article
- Comparative Genomics Reveals Biomarkers to Identify Lactobacillus Species.Indian journal of microbiology · 2016Article
- Complete genome sequence and description ofNew microbes and new infections · 2016Article
- Antiviral effects of Lactobacillus ruminis SPM0211 and Bifidobacterium longum SPM1205 and SPM1206 on rotavirus-infected Caco-2 cells and a neonatal mouse model.Journal of microbiology (Seoul, Korea) · 2015Article
- Lactobacillus ruminis strains cluster according to their mammalian gut source.BMC microbiology · 2015Article
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8 authors.
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Abstract
backgroundThe genus Lactobacillus is characterized by an extraordinary degree of phenotypic and genotypic diversity, which recent genomic analyses have further highlighted. However, the choice of species for sequencing has been non-random and unequal in distribution, with only a single representative genome from the L. salivarius clade available to date. Furthermore, there is no data to facilitate a functional genomic analysis of motility in the lactobacilli, a trait that is restricted to the L. salivarius clade.
resultsThe 2.06 Mb genome of the bovine isolate Lactobacillus ruminis ATCC 27782 comprises a single circular chromosome, and has a G+C content of 44.4%. In silico analysis identified 1901 coding sequences, including genes for a pediocin-like bacteriocin, a single large exopolysaccharide-related cluster, two sortase enzymes, two CRISPR loci and numerous IS elements and pseudogenes. A cluster of genes related to a putative pilin was identified, and shown to be transcribed in vitro. A high quality draft assembly of the genome of a second L. ruminis strain, ATCC 25644 isolated from humans, suggested a slightly larger genome of 2.138 Mb, that exhibited a high degree of synteny with the ATCC 27782 genome. In contrast, comparative analysis of L. ruminis and L. salivarius identified a lack of long-range synteny between these closely related species. Comparison of the L. salivarius clade core proteins with those of nine other Lactobacillus species distributed across 4 major phylogenetic groups identified the set of shared proteins, and proteins unique to each group.
conclusionsThe genome of L. ruminis provides a comparative tool for directing functional analyses of other members of the L. salivarius clade, and it increases understanding of the divergence of this distinct Lactobacillus lineage from other commensal lactobacilli. The genome sequence provides a definitive resource to facilitate investigation of the genetics, biochemistry and host interactions of these motile intestinal lactobacilli.
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