ArticleThe Journal of clinical endocrinology and metabolism2011
Disassociation of liver and muscle insulin resistance from ectopic lipid accumulation in low-birth-weight individuals.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Hypoxic pregnancy promotes fibrosis and increases stress metabolites in the ovine fetal liver.The Journal of physiology · 2025Article
- Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus.JCI insight · 2024Article
- Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals.Environmental health and preventive medicine · 2013Review
- Leptin may enhance hepatic insulin sensitivity in children and women born small for gestational age.Endocrine connections · 2013Article
- Article
- UPDATING THE CONCEPT OF METABOLICALLY HEALTHY OBESITY.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
contextLow birth weight (LBW) is a marker of fetal stress and is associated with an increased prevalence of type 2 diabetes (T2D). Insulin resistance plays a prominent role in the development of T2D; however, the pathogenesis of T2D in LBW is controversial.
objectiveThe objective of the study was to assess whole-body and tissue-specific insulin sensitivity and intramyocellular lipid (IMCL) and hepatic lipid content in LBW and matched control subjects.
designThese were prospective and pair-matched studies.
settingThe study was conducted at Yale University Center for Clinical Investigation.
participantsYoung, lean, nonsmoking, sedentary LBW (n = 45) and matched control subjects participated in the study.
interventionInterventions included an oral glucose tolerance test and hyperinsulinemic-euglycemic clamps and (1)H magnetic resonance spectroscopy. MAIN OUTCOMES MEASURES: The main outcomes measures included insulin sensitivity index; whole-body and tissue-specific insulin sensitivity; liver lipid and IMCL contents; and fasting concentrations of cortisol, GH, and IGF-I as markers of the hypothalamic-pituitary-adrenal and IGFI/GH axes.
resultsThe LBW subjects were insulin resistant as reflected by a 20% reduction in insulin sensitivity index as compared with the controls (P = 0.0017), which could be attributed to both liver and muscle insulin resistance. There were no differences in IMCL or hepatic triglyceride content between LBW and control groups. In the LBW group, fasting plasma concentrations of cortisol (P = 0.01) and GH (P = 0.01) were increased, and IGF-I concentrations reduced (P < 0.05) a pattern, which may suggest potential dysregulation of the hypothalamic-pituitary-adrenal and IGF-I/GH axes.
conclusionThese results support the hypothesis that fetal stress and LBW lead to liver and muscle insulin resistance and show that this is independent of lipid deposition in these organs.
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