ArticleAmerican journal of cancer research2011
Intravital microscopy in the mouse dorsal chamber model for the study of solid tumors.
Article in American journal of cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- From lab to life: technological innovations in transforming cancer metastasis detection and therapy.Discover oncology · 2025Review
- Hyperspectral imaging of 4T1 mammary carcinomas grown in dorsal skinfold window chambers: spectral renormalization and fluorescence modeling.Journal of biomedical optics · 2024Article
- Intravital longitudinal cellular visualization of oral mucosa in a murine model based on rotatory side-view confocal endomicroscopy.Biomedical optics express · 2022Article
- 3D-printed lightweight dorsal skin fold chambers from PEEK reduce chamber-related animal distress.Scientific reports · 2022Article
- Article
- Preclinical longitudinal imaging of tumor microvascular radiobiological response with functional optical coherence tomography.Scientific reports · 2018Article
- Intravital Monitoring of Vasculature After Targeted Gene Therapy Alone or Combined With Tumor Irradiation.Technology in cancer research & treatment · 2018Article
- Dorsal skinfold chamber models in mice.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2017Article
- Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.Nature nanotechnology · 2016Article
- Improving Nanoparticle Penetration in Tumors by Vascular Disruption with Acoustic Droplet Vaporization.Theranostics · 2016Article
- Optimization of the dorsal skinfold window chamber model and multi-parametric characterization of tumor-associated vasculature.Intravital · 2014Article
- IMART software for correction of motion artifacts in images collected in intravital microscopy.IntravitalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Intra-Vital Microscopy (IVM) is used to visualize tumors in animals and analyze various aspects of cancer physiology such as tumor vascularization, cell migration and metastasis. The main advantages of IVM include the real -time analysis of dynamic processes with single-cell resolution. The application of IVM, however, is limited by the availability of animal models that carry visually accessible tumors. These models have evolved over time to become more and more relevant to human tumors. The latest step is the development of a pseudo-orthotopic, syngeneic model for tumor growth and metastasis. In this model, tissue from a variety of mouse organs are grafted in a dorsal skinfold chamber and allowed to revascularize, whereupon tumor cell spheroids are implanted. These spheroids develop into tumors that bear a much closer resemblance to human tumors than xenografts. Unlike xenografts, the vasculature is well-ordered and, because the model is syngeneic, there are no cross-species host immune reactions. The use of fluorescence-tagged pseudo-organs and tumor cells allows IVM analysis and provides real-time access to the development of tumors that closely resemble the real disease. This model can be used to test therapeutics and to image tumor development and stroma-tumor interactions.
Indexed as
Identifiers
21994905PMC3189827W195312834What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.