Evidence map›Paper›PMID 21994796›Full record

ReviewViruses2011

Dengue--quo tu et quo vadis?

Rubing Chen, Nikos Vasilakis

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Viruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03612609 (Pilot Study to Detect DENGUE Virus in Sperm.), which is not on this map. Cited by 170 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 2 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03612609 nacompletednot on this mapstarted 2019, after this paper: background citation

Pilot Study to Detect DENGUE Virus in Sperm.

TypeinterventionalSponsorUniversity Hospital, ToulouseRan2019 to 2019Enrolled10ConditionsDengueArmsblood, urine and semen sample
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 2 syntheses or guidelines pooled it, 319 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Viral genetic diversity and protective efficacy of a tetravalent dengue vaccine in two phase 3 trials.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Dengue: Historical Aspects.Current topics in microbiology and immunology · 2026
    Article
  13. Article
  14. Dengue Vaccines.Current topics in microbiology and immunology · 2026
    Review
  15. Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rubing ChenDepartment of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. ruchen@utmb.edu
Nikos Vasilakis
The University of Texas Medical Branch at Galveston · US

Funding

Mechanisms of sylvatic dengue emergenceR01AI069145 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2008 to 2011
$2.5M
NIAID NIH HHS AI069145NIAID NIH HHS R01 AI069145
6 · The paper itself

Abstract

Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics around the world, putting at risk of infection nearly a third of the global human population. DENV are members of the genus Flavivirus in the Family Flaviviridae and comprise four antigenically distinct serotypes (DENV-1-4). Although they share almost identical epidemiological features, they are genetically distinct. Phylogenetic analyses have revealed valuable insights into the origins, epidemiology and the forces that shape DENV evolution in nature. In this review, we examine the current status of DENV evolution, including but not limited to rates of evolution, selection pressures, population sizes and evolutionary constraints, and we discuss how these factors influence transmission, pathogenesis and emergence.

Indexed as

Evolution, MolecularPhylogenyAedesAnimalsDengueDengue VirusGenetic VariationHumansInsect VectorsSelection, Geneticarbovirusdengue virus (DENV)evolutionmosquitophylogenetics

Identifiers

PMID21994796
PMCPMC3187692
OpenAlexW2118130809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.