ReviewViruses2011
Viruses, autophagy genes, and Crohn's disease.
Review in Viruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- A systematic review and functional bioinformatics analysis of genes associated with Crohn's disease identify more than 120 related genes.BMC genomics · 2022Pooled it
- Article
- The roles and functions of Paneth cells in Crohn's disease: A critical review.Cell proliferation · 2021Review
- Composition of the Intestinal Microbiota Determines the Outcome of Virus-Triggered Colitis in Mice.Frontiers in immunology · 2019Article
- Enteric Infections Are Common in Patients with Flares of Inflammatory Bowel Disease.The American journal of gastroenterology · 2018Article
- The Intestinal Virome and Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice.The American journal of pathology · 2018Article
- Paneth Cells during Viral Infection and Pathogenesis.Viruses · 2018Review
- Norovirus Regulation by Host and Microbe.Trends in molecular medicine · 2016Review
- Autophagy, viruses, and intestinal immunity.Current opinion in gastroenterology · 2014Review
- Biological pathways involved in the development of inflammatory bowel disease.Wiener klinische Wochenschrift · 2014Review
- The role of type I interferons in intestinal infection, homeostasis, and inflammation.Immunological reviews · 2014Review
- A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection.Cell host & microbe · 2013Article
- Human enterovirus species B in ileocecal Crohn's disease.Clinical and translational gastroenterology · 2013Article
- Study of the viral and microbial communities associated with Crohn's disease: a metagenomic approach.Clinical and translational gastroenterology · 2013Article
- Autophagy and the regulation of the immune response.Pharmacological research · 2012Review
- Crohn's and colitis in children and adolescents.World journal of gastroenterology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of the intestinal disease Crohn's disease involves genetic factors as well as ill-defined environmental agents. Several genetic variants linked to this disease are associated with autophagy, a process that is critical for proper responses to viral infections. While a role for viruses in this disease remains speculative, accumulating evidence indicate that this possibility requires serious consideration. In this review, we will examine the three-way relationship between viruses, autophagy genes, and Crohn's disease and discuss how host-pathogen interactions can mediate complex inflammatory disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.