Evidence map›Paper›PMID 21994729›Full record

ArticleViruses2011

A new role for the HTLV-1 p8 protein: increasing intercellular conduits and viral cell-to-cell transmission.

Marine Malbec, Ferdinand Roesch, Olivier Schwartz

Abstract read
In one paragraph

Article in Viruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Tunneling Nanotubes: The Cables for Viral Spread and Beyond.Results and problems in cell differentiation · 2024
    Review
  3. A role for tunneling nanotubes in virus spread.Frontiers in microbiology · 2024
    Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marine MalbecVirus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.
Ferdinand RoeschVirus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.
Olivier SchwartzVirus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr. Roux, 75724 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retroviruses like HIV-1 and HTLV-1 can be transmitted efficiently by direct contact between infected and target cells. For HIV-1, various modes of cell-to-cell transfer have been reported, including virological synapses, polysynapses, filopodial bridges, and nanotube-like structures. So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8.

Indexed as

Cell LineHTLV-I InfectionsHumansHuman T-lymphotropic virus 1Viral Regulatory and Accessory ProteinsViral Regulatory and Accessory Proteinscell-to-cell transfercellular conduitsHIV-1HTLV-1Nefp12p8virological synapses

Identifiers

PMID21994729
PMCPMC3185692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.