ArticleViruses2011
A strong case for viral genetic factors in HIV virulence.
Article in Viruses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission.AIDS (London, England) · 2012Pooled it
- Phylogenetics and molecular evolution to understand and curb the HIV pandemic.Nature reviews. Microbiology · 2026Review
- Evolution of HIV virulence in response to disease-modifying vaccines: A modeling study.Vaccine · 2023Article
- Review
- Herpes Simplex Virus-2 Variation Contributes to Neurovirulence During Neonatal Infection.The Journal of infectious diseases · 2022Article
- Human Adenovirus Type 4 Comprises Two Major Phylogroups with Distinct Replicative Fitness and Virulence Phenotypes.Journal of virology · 2022Article
- Genotypic and Phenotypic Diversity of Herpes Simplex Virus 2 within the Infected Neonatal Population.mSphere · 2019Article
- Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.Molecular biology and evolution · 2018Article
- Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.PLoS computational biology · 2017Article
- Prognostic Value of HIV-1 RNA on CD4 Trajectories and Disease Progression Among Antiretroviral-Naive HIV-Infected Adults in Botswana: A Joint Modeling Analysis.AIDS research and human retroviruses · 2016Article
- The impact of antiretroviral therapy on population-level virulence evolution of HIV-1.Journal of the Royal Society, Interface · 2015Article
- High heritability is compatible with the broad distribution of set point viral load in HIV carriers.PLoS pathogens · 2015Article
- Immuno-epidemiological modeling of HIV-1 predicts high heritability of the set-point virus load, while selection for CTL escape dominates virulence evolution.PLoS computational biology · 2014Article
- The HIV epidemic in Southern Africa - Is an AIDS-free generation possible?Current HIV/AIDS reports · 2014Review
- Evidence that hepatitis C virus genome partly controls infection outcome.Evolutionary applications · 2014Article
- The contribution of viral genotype to plasma viral set-point in HIV infection.PLoS pathogens · 2014Article
- Is HIV short-sighted? Insights from a multistrain nested model.Evolution; international journal of organic evolution · 2013Article
- How effectively can HIV phylogenies be used to measure heritability?Evolution, medicine, and public health · 2013Article
- Evolutionary dynamics of HIV at multiple spatial and temporal scales.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Variable effect of co-infection on the HIV infectivity: within-host dynamics and epidemiological significance.Theoretical biology & medical modelling · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four studies [1-4] published within a year has filled this important gap and has demonstrated a robust effect of the viral genotype on HIV virulence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.