Evidence map›Paper›PMID 21994669›Full record

ArticleViruses2010

Glycosphingolipids as receptors for non-enveloped viruses.

Stefan Taube, Mengxi Jiang, Christiane E Wobus

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 102 citations in OpenAlex.

  1. Article
  2. Gangliosides in molecular interactions and cell regulation.The Journal of biological chemistry · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Norovirus-glycan interactions - how strong are they really?Biochemical Society transactions · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Dyslipidemia in breast cancer patients increases the risk of SAR-CoV-2 infection.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Stefan TaubeDepartment of Microbiology and Immunology, University of Michigan Medical School, 5622 Medical Sciences Bldg. II, 1150 West Medical Center Dr., Ann Arbor, MI 48109, USA.
Mengxi JiangDepartment of Microbiology and Immunology, University of Michigan Medical School, 5622 Medical Sciences Bldg. II, 1150 West Medical Center Dr., Ann Arbor, MI 48109, USA.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan Medical School, 5622 Medical Sciences Bldg. II, 1150 West Medical Center Dr., Ann Arbor, MI 48109, USA.ORCID 0000-0001-5286-0924
Forschungszentrum Jülich · DEUniversity of Michigan · USUniversity of Missouri–St. Louis · US

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI SCHLESINGER, LARRY S. · 2003 to 2013
$87.6M
Mechanisms of Norovirus EntryR01AI080611 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOBUS, CHRISTIANE · 2009 to 2012
$1.5M
NIAID NIH HHS R01 AI080611NIAID NIH HHS U54 AI057153
6 · The paper itself

Abstract

Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma- and parvovirus families.

Indexed as

calicivirusglycosphingolipidnon-enveloped virusparvoviruspolyomavirusreceptorrotavirus

Identifiers

PMID21994669
PMCPMC3185660
OpenAlexW2138505582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.