ArticleViruses2010
Buying time-the immune system determinants of the incubation period to respiratory viruses.
Article in Viruses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Estimates of epidemiological parameters for H5N1 influenza in humans: a rapid review.BMC infectious diseases · 2025Pooled it
- Assessing changes in incubation period, serial interval, and generation time of SARS-CoV-2 variants of concern: a systematic review and meta-analysis.BMC medicine · 2023Pooled it
- Immune Delay, Beyond Immune Evasion, as a Driver of Pathogen Propagation Competence Through Neutrophil Dysregulation, to be Mitigated by Low-Frequency Electromagnetic Fields (LF-EMF).International journal of molecular sciences · 2025Review
- Defining the Critical Requisites for Accurate Simulation of SARS-CoV-2 Viral Dynamics: Patient Characteristics and Data Collection Protocol.Journal of medical virology · 2025Article
- Latent and incubation periods of Delta, BA.1, and BA.2 variant cases and associated factors: a cross-sectional study in China.BMC infectious diseases · 2024Article
- Genomic epidemiology offers high resolution estimates of serial intervals for COVID-19.Nature communications · 2023Article
- Incubation period, clinical and lung CT features for early prediction of COVID-19 deterioration: development and internal verification of a risk model.BMC pulmonary medicine · 2022Article
- Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein.Nature communications · 2022Article
- Epidemiological features of COVID-19 patients with prolonged incubation period and its implications for controlling the epidemics in China.BMC public health · 2021Article
- Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India.Virology · 2021Article
- Shorter incubation period is associated with severe disease progression in patients with COVID-19.Virulence · 2020Article
- Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection.EClinicalMedicine · 2020Article
- Viruses of Respiratory Tract: an Observational Retrospective Study on Hospitalized Patients in Rome, Italy.Microorganisms · 2020Article
- Probable Longer Incubation Period for Elderly COVID-19 Cases: Analysis of 180 Contact Tracing Data in Hubei Province, China.Risk management and healthcare policy · 2020Article
- Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection.Pathogens (Basel, Switzerland) · 2019Review
- Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I.mBio · 2015Article
- Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes.PloS one · 2014Article
- Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection.PLoS pathogens · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Respiratory viruses cause disease in humans characterized by an abrupt onset of symptoms. Studies in humans and animal models have shown that symptoms are not immediate and appear days or even weeks after infection. Since the initial symptoms are a manifestation of virus recognition by elements of the innate immune response, early virus replication must go largely undetected. The interval between infection and the emergence of symptoms is called the incubation period and is widely used as a clinical score. While incubation periods have been described for many virus infections the underlying mechanism for this asymptomatic phase has not been comprehensively documented. Here we review studies of the interaction between human pathogenic respiratory RNA viruses and the host with a particular emphasis on the mechanisms used by viruses to inhibit immunity. We discuss the concept of the "stealth phase", defined as the time between infection and the earliest detectable inflammatory response. We propose that the "stealth phase" phenomenon is primarily responsible for the suppression of symptoms during the incubation period and results from viral antagonism that inhibits major pathways of the innate immune system allowing an extended time of unhindered virus replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.