Evidence map›Paper›PMID 21994604›Full record

ArticleViruses2010

RNA editing and its control in hepatitis delta virus replication.

Renxiang Chen, Sarah D Linnstaedt, John L Casey

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Nuclear domain 10 of the viral aspect.World journal of virology · 2013
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Renxiang ChenDepartment of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
Sarah D LinnstaedtDepartment of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
John L CaseyDepartment of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
Georgetown University · USGeorgetown University Medical Center · US

Funding

HEPATITIS DELTA VIRUS RNA EDITINGR01AI042324 · NIAID · GEORGETOWN UNIVERSITY · PI CASEY, JOHN L · 1999 to 2007
$1.9M
NIAID NIH HHS R01 AI042324
6 · The paper itself

Abstract

The hepatitis delta virus genome is a small circular RNA, similar to viroids. Although HDV contains a gene, the protein produced (HDAg) is encoded by less than half the genome and possesses no RNA polymerase activity. Because of this limited coding capacity, HDV relies heavily on host functions and on structural features of the viral RNA-very much like viroids. The virus' use of host RNA editing activity to produce two functionally distinct forms of HDAg is a particularly good example of this reliance. This review covers the mechanisms and control of RNA editing in the HDV replication cycle.

Indexed as

ADAR1hepatitis delta antigenhepatitis delta virusRNA editingRNA-protein interactionsRNA structural dynamicsRNA structure

Identifiers

PMID21994604
PMCPMC3185552
OpenAlexW2063481590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.