ArticleViruses2009
Defective Interfering RNAs: Foes of Viruses and Friends of Virologists.
Article in Viruses, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 109 citations in OpenAlex.
- Article
- Identification, functional analysis, and clinical applications of defective viral genomes.Frontiers in microbiology · 2025Review
- An innovative infection method for the accumulation of viral nanoparticles inFrontiers in plant science · 2025Article
- Examining intra-host genetic variation of RSV by short read high-throughput sequencing.bioRxiv : the preprint server for biology · 2024Article
- Intra-Host Citrus Tristeza Virus Populations during Prolonged Infection Initiated by a Well-Defined Sequence Variant inViruses · 2024Article
- Unraveling the genomic landscape of piscine myocarditis virus: mutation frequencies, viral diversity and evolutionary dynamics in Atlantic salmon.Virus evolution · 2024Article
- Reverse Genetics System for Rift Valley Fever Virus.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Conserved untranslated regions of multipartite viruses: Natural markers of novel viral genomic components and tags of viral evolution.Virus evolution · 2024Article
- Roles of long non-coding RNAs in plant immunity.PLoS pathogens · 2023Review
- Cheating leads to the evolution of multipartite viruses.PLoS biology · 2023Article
- Proof-of-concept for effective antiviral activity of anFrontiers in microbiology · 2023Article
- Review
- Lessons Learned and Yet-to-Be Learned on the Importance of RNA Structure in SARS-CoV-2 Replication.Microbiology and molecular biology reviews : MMBR · 2022Review
- Genetic Diversity of Tomato Black Ring Virus Satellite RNAs and Their Impact on Virus Replication.International journal of molecular sciences · 2022Article
- Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts.Methods (San Diego, Calif.) · 2022Article
- sgDI-tector: defective interfering viral genome bioinformatics for detection of coronavirus subgenomic RNAs.RNA (New York, N.Y.) · 2022Article
- The evolution of cheating in viruses.Nature communications · 2021Review
- Review
- The strand-biased transcription of SARS-CoV-2 and unbalanced inhibition by remdesivir.iScience · 2021Article
- The SARS-CoV-2 subgenome landscape and its novel regulatory features.Molecular cell · 2021Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Defective interfering (DI) RNAs are subviral RNAs produced during multiplication of RNA viruses by the error-prone viral replicase. DI-RNAs are parasitic RNAs that are derived from and associated with the parent virus, taking advantage of viral-coded protein factors for their multiplication. Recent advances in the field of DI RNA biology has led to a greater understanding about generation and evolution of DI-RNAs as well as the mechanism of symptom attenuation. Moreover, DI-RNAs are versatile tools in the hands of virologists and are used as less complex surrogate templates to understand the biology of their helper viruses. The ease of their genetic manipulation has resulted in rapid discoveries on cis-acting RNA replication elements required for replication and recombination. DI-RNAs have been further exploited to discover host factors that modulate Tomato bushy stunt virus replication, as well as viral RNA recombination. This review discusses the current models on generation and evolution of DI-RNAs, the roles of viral and host factors in DI-RNA replication, and the mechanisms of disease attenuation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.