ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2011
Prenatal smoke exposure and genomic DNA methylation in a multiethnic birth cohort.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.Annals of global health · 2018Pooled it
- DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.American journal of human genetics · 2016Pooled it
- Modulation of DNA methylation states and infant immune system by dietary supplementation with ω-3 PUFA during pregnancy in an intervention study.The American journal of clinical nutrition · 2013Trial
- Early-life exposure to cigarette smoke primes lung function and DNA methylation changes atAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis.Clinical epigenetics · 2022Article
- Prenatal Maternal Smoke, DNA Methylation, and Multi-omics of Tissues and Child Health.Current environmental health reports · 2022Review
- Impact of the Exposome on the Epigenome in Inflammatory Bowel Disease Patients and Animal Models.International journal of molecular sciences · 2022Review
- DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure†.Biology of reproduction · 2021Review
- Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review.International journal of environmental research and public health · 2021Review
- Immediate and durable effects of maternal tobacco consumption alter placental DNA methylation in enhancer and imprinted gene-containing regions.BMC medicine · 2020Article
- DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.Croatian medical journal · 2020Article
- Prenatal epigenetics diets play protective roles against environmental pollution.Clinical epigenetics · 2019Review
- Associations between Maternal Tobacco Smoke Exposure and the Cord BloodEnvironmental health perspectives · 2019Article
- Maternal LINE-1 DNA Methylation and Congenital Heart Defects in Down Syndrome.Frontiers in genetics · 2019Article
- Prenatal influences on temperament development: The role of environmental epigenetics.Development and psychopathology · 2018Review
- DNA methylation as a marker for prenatal smoke exposure in adults.International journal of epidemiology · 2018Article
- Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health.Scientific reports · 2018Article
- Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife.Epigenetics · 2018Article
- Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis.Scientific reports · 2017Article
- Prenatal airborne polycyclic aromatic hydrocarbon exposure, LINE1 methylation and child development in a Chinese cohort.Environment international · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExposure to prenatal tobacco smoke (PTS) has been associated with a number of health outcomes in the offspring, including some childhood cancers. Lower levels of genomic DNA methylation have also been associated with several types of cancers. We investigated whether PTS was associated with global DNA methylation levels in the offspring.
methodsOur sample was drawn from a birth cohort of women born between 1959 and 1963 in New York City (n = 90). We measured methylation of repetitive elements (Sat2, Alu, LINE-1) from peripheral blood granulocytes. We combined prospectively collected data on PTS with adult epidemiologic data and blood samples collected in 2001 to 2007 (mean age, 43 years). We used linear regression to assess the association between PTS and repetitive element methylation.
resultsThirty-six percent of mothers smoked during pregnancy. We observed an inverse association between PTS and Sat2 methylation. This inverse association remained even after adjustment for potential mediators including child environmental tobacco smoke exposure, birth size, postnatal weight and height changes, and adult smoking status and alcohol intake (β = -0.22, 95% confidence interval = -0.40 to -0.03 for ever exposed to PTS vs. never exposed using models of log-transformed methylation levels). PTS exposure was not statistically significantly associated with LINE-1 or Alu methylation.
conclusionsPTS exposure, measured at the time of pregnancy and not retrospectively reported, was associated with a decrease in Sat2 methylation but not LINE-1 or Alu methylation. IMPACT: If replicated in larger studies, this study supports a persistent effect of PTS on DNA methylation levels, as measured by Sat2, in adulthood.
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