ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
A diversity of synaptic filters are created by temporal summation of excitation and inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- High-Pass Filtering through Short-Term Synaptic Facilitation Amplifies Low-Frequency Modulation of Bursting Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales.Journal of computational neuroscience · 2025Article
- Spike timing-dependent plasticity alters electrosensory neuron synaptic strength in vitro but does not consistently predict changes in sensory tuning in vivo.Journal of neurophysiology · 2023Article
- A synaptic filtering mechanism in visual threat identification in mouse.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Exploratory evaluation of spinal cord stimulation with dynamic pulse patterns: a promising approach to improve stimulation sensation, coverage of pain areas, and expected pain relief.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Object Boundary Detection in Natural Images May Depend on "Incitatory" Cell-Cell Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Temporal filters in response to presynaptic spike trains: interplay of cellular, synaptic and short-term plasticity time scales.Journal of computational neuroscience · 2022Article
- How auditory selectivity for sound timing arises: The diverse roles of GABAergic inhibition in shaping the excitation to interval-selective midbrain neurons.Progress in neurobiology · 2021Article
- Auditory DUM neurons in a bush-cricket: inhibited inhibitors.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Periodicity Pitch Perception.Frontiers in neuroscience · 2020Article
- Acoustic Pattern Recognition and Courtship Songs: Insights from Insects.Annual review of neuroscience · 2019Review
- Short-Term Synaptic Plasticity as a Mechanism for Sensory Timing.Trends in neurosciences · 2018Review
- The cellular and circuit basis for evolutionary change in sensory perception in mormyrid fishes.Scientific reports · 2017Article
- Behavioral and Single-Neuron Sensitivity to Millisecond Variations in Temporally Patterned Communication Signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Postnatal maturation of GABAergic modulation of sensory inputs onto lateral amygdala principal neurons.The Journal of physiology · 2015Article
- Species-specificity of temporal processing in the auditory midbrain of gray treefrogs: interval-counting neurons.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Short-term depression, temporal summation, and onset inhibition shape interval tuning in midbrain neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Diverse thalamocortical short-term plasticity elicited by ongoing stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- A fast BK-type KCa current acts as a postsynaptic modulator of temporal selectivity for communication signals.Frontiers in cellular neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Temporal filtering is a fundamental operation of nervous systems. In peripheral sensory systems, the temporal pattern of spiking activity can encode various stimulus qualities, and temporal filtering allows postsynaptic neurons to detect behaviorally relevant stimulus features from these spike trains. Intrinsic excitability, short-term synaptic plasticity, and voltage-dependent dendritic conductances have all been identified as mechanisms that can establish temporal filtering behavior in single neurons. Here we show that synaptic integration of temporally summating excitation and inhibition can establish diverse temporal filters of presynaptic input. Mormyrid electric fish communicate by varying the intervals between electric organ discharges. The timing of each discharge is coded by peripheral receptors into precisely timed spikes. Within the midbrain posterior exterolateral nucleus, temporal filtering by individual neurons results in selective responses to a particular range of presynaptic interspike intervals. These neurons are diverse in their temporal filtering properties, reflecting the wide range of intervals that must be detected during natural communication behavior. By manipulating presynaptic spike timing with high temporal resolution, we demonstrate that tuning to behaviorally relevant patterns of presynaptic input is similar in vivo and in vitro. We reveal that GABAergic inhibition plays a critical role in establishing different temporal filtering properties. Further, our results demonstrate that temporal summation of excitation and inhibition establishes selective responses to high and low rates of synaptic input, respectively. Simple models of synaptic integration reveal that variation in these two competing influences provides a basic mechanism for generating diverse temporal filters of synaptic input.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.