ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Axonal Localization of transgene mRNA in mature PNS and CNS neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 78 citations in OpenAlex.
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- Secretory pathway in honeybee venom and actin: evidence from chemical-biological interactions.Human cell · 2025Article
- Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Deciphering the molecular landscape of human peripheral nerves: implications for diabetic peripheral neuropathy.bioRxiv : the preprint server for biology · 2024Article
- Spinal cord injury regulates circular RNA expression in axons.Frontiers in molecular neuroscience · 2023Article
- Involvement of the miR-363-5p/P2RX4 Axis in Regulating Schwann Cell Phenotype after Nerve Injury.International journal of molecular sciences · 2021Article
- Article
- Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy.Frontiers in molecular neuroscience · 2021Article
- Emerging Roles for 3' UTRs in Neurons.International journal of molecular sciences · 2020Review
- Axon microdissection and transcriptome profiling reveals the in vivo RNA content of fully differentiated myelinated motor axons.RNA (New York, N.Y.) · 2020Article
- Detection of Differentially Expressed Cleavage Site Intervals Within 3' Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs.Frontiers in genetics · 2019Article
- The Role of Axon Transport in Neuroprotection and Regeneration.Developmental neurobiology · 2018Review
- Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met.Frontiers in cellular neuroscience · 2018Review
- Analysis of piRNA-Like Small Non-coding RNAs Present in Axons of Adult Sensory Neurons.Molecular neurobiology · 2018Article
- Framework for reanalysis of publicly available Affymetrix® GeneChip® data sets based on functional regions of interest.BMC genomics · 2017Article
- Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons.The Journal of cell biology · 2017Article
- Accumulating Evidence for Axonal Translation in Neuronal Homeostasis.Frontiers in neuroscience · 2017Review
- Protein synthetic machinery and mRNA in regenerating tips of spinal cord axons in lamprey.The Journal of comparative neurology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Axonal mRNA transport is robust in cultured neurons but there has been limited evidence for this in vivo. We have used a genetic approach to test for in vivo axonal transport of reporter mRNAs. We show that β-actin's 3'-UTR can drive axonal localization of GFP mRNA in mature DRG neurons, but mice with γ-actin's 3'-UTR show no axonal GFP mRNA. Peripheral axotomy triggers transport of the β-actin 3'-UTR containing transgene mRNA into axons. This GFP-3'-β-actin mRNA accumulates in injured PNS axons before activation of the transgene promoter peaks in the DRG. Spinal cord injury also increases axonal GFP signals in mice carrying this transgene without any increase in transgene expression in the DRGs. These data show for the first time that the β-actin 3'-UTR is sufficient for axonal localization in both PNS and CNS neurons in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.