ArticleJournal of neurophysiology2012
Low-threshold calcium currents contribute to locomotor-like activity in neonatal mice.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Properties of rhythmogenic currents in spinal Shox2 interneurons across postnatal development.The Journal of physiology · 2025Article
- Multiple patterns of persistent inward currents with multiple types of repetitive firings in medullary serotonergic neurons of mice: An experimental and modeling study.PLoS computational biology · 2025Article
- Asymmetric and transient properties of reciprocal activity of antagonists during the paw-shake response in the cat.PLoS computational biology · 2021Article
- Article
- Elimination of glutamatergic transmission from Hb9 interneurons does not impact treadmill locomotion.Scientific reports · 2021Article
- Critical Components for Spontaneous Activity and Rhythm Generation in Spinal Cord Circuits in Culture.Frontiers in cellular neuroscience · 2020Article
- Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.Frontiers in neural circuits · 2020Article
- The rhythm section: An update on spinal interneurons setting the beat for mammalian locomotion.Current opinion in physiology · 2019Article
- Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator.Journal of neurophysiology · 2018Article
- Premotor Neuron Divergence Reflects Vocal Evolution.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury.The Journal of physiology · 2018Article
- Modulation of gamma and alpha spinal motor neurons activity by trans-spinal direct current stimulation: effects on reflexive actions and locomotor activity.Physiological reports · 2016Article
- Graded boosting of synaptic signals by low-threshold voltage-activated calcium conductance.Journal of neurophysiology · 2015Article
- Activity-dependent changes in extracellular Ca2+ and K+ reveal pacemakers in the spinal locomotor-related network.Neuron · 2013Article
- TTX-resistant NMDA receptor-mediated membrane potential oscillations in neonatal mouse Hb9 interneurons.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In this study, we examined the contribution of a low-threshold calcium current [I(Ca(T))] to locomotor-related activity in the neonatal mouse. Specifically, the role of I(Ca(T)) was studied during chemically induced, locomotor-like activity in the isolated whole cord and in a genetically distinct population of ventromedial spinal interneurons marked by the homeobox gene Hb9. In isolated whole spinal cords, cycle frequency was decreased in the presence of low-threshold calcium channel blockers, which suggests a role for I(Ca(T)) in the network that produces rhythmic, locomotor-like activity. Additionally, we used Hb9 interneurons as a model to study the cellular responses to application of low-threshold calcium channel blockers. In transverse slice preparations from transgenic Hb9::enhanced green fluorescent protein neonatal mice, N-methyl-d-aspartate-induced membrane potential oscillations in identified Hb9 interneurons also slowed in frequency with application of nickel when fast, spike-mediated, synaptic transmission was blocked with TTX. Voltage-clamp and immunolabeling experiments confirmed expression of I(Ca(T)) and channels, respectively, in Hb9 interneurons located in the ventromedial spinal cord. Taken together, these results provide support that T-type calcium currents play an important role in network-wide rhythm generation during chemically evoked, fictive locomotor activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.