ArticleBioinformatics (Oxford, England)2011
Pico-inplace-inversions between human and chimpanzee.
Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Characteristics and possible mechanisms of formation of microinversions distinguishing human and chimpanzee genomes.Scientific reports · 2022Article
- The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans.Interdisciplinary sciences, computational life sciences · 2020Article
- A survey of localized sequence rearrangements in human DNA.Nucleic acids research · 2018Article
- Split-alignment of genomes finds orthologies more accurately.Genome biology · 2015Article
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4 authors.
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Abstract
motivationThere have been several studies on the micro-inversions between human and chimpanzee, but there are large discrepancies among their results. Furthermore, all of them rely on alignment procedures or existing alignment results to identify inversions. However, the core alignment procedures do not take very small inversions into consideration. Therefore, their analyses cannot find inversions that are too small to be detected by a classic aligner. We call such inversions pico-inversions.
resultsWe re-analyzed human-chimpanzee alignment from the UCSC Genome Browser for micro-inplace-inversions and screened for pico-inplace-inversions using a likelihood ratio test. We report that the quantity of inplace-inversions between human and chimpanzee is substantially greater than what had previously been discovered. We also present the software tool PicoInversionMiner to detect pico-inplace-inversions between closely related species. AVAILABILITY: Software tools, scripts and result data are available at http://faculty.cs.niu.edu/~hou/PicoInversion.html. CONTACT: mhou@cs.niu.edu.
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