Evidence map›Paper›PMID 21994220›Full record

ArticleBioinformatics (Oxford, England)2011

FlyExpress: visual mining of spatiotemporal patterns for genes and publications in Drosophila embryogenesis.

Sudhir Kumar, Charlotte Konikoff, Bernard Van Emden, Christopher Busick, Kailah T Davis, Shuiwang Ji, Lin-Wei Wu, Hector Ramos, Thomas Brody, Sethuraman Panchanathan and 5 more

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Using FlyBase: A Database of Drosophila Genes and Genetics.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Review
  5. The Roles of the LIM Domain Proteins inFrontiers in cardiovascular medicine · 2021
    Review
  6. Article
  7. Article
  8. TheDisease models & mechanisms · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Using FlyBase, a Database of Drosophila Genes and Genomes.Methods in molecular biology (Clifton, N.J.) · 2016
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sudhir KumarCenter for Evolutionary Medicine and Informatics, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA. s.kumar@asu.edu
Charlotte Konikoff
Bernard Van Emden
Christopher Busick
Kailah T Davis
Shuiwang Ji
Lin-Wei Wu
Hector Ramos
Thomas Brody
Sethuraman Panchanathan
Jieping Ye
Timothy L Karr
Kristyn Gerold
Michael McCutchan
Stuart J Newfeld

Funding

Computatonal Analysis of Gene Expression Pattern ImagesR01HG002516 · NHGRI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI KUMAR, SUDHIR · 2003 to 2013
$5.3M
Arizona State University PREP for Biomedical ResearchR25GM071798 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI HOGUE, BRENDA G. · 2004 to 2014
$2.4M
NHGRI NIH HHS HG002516-07NHGRI NIH HHS R01 HG002516NIGMS NIH HHS R25 GM071798
6 · The paper itself

Abstract

summaryImages containing spatial expression patterns illuminate the roles of different genes during embryogenesis. In order to generate initial clues to regulatory interactions, biologists frequently need to know the set of genes expressed at the same time at specific locations in a developing embryo, as well as related research publications. However, text-based mining of image annotations and research articles cannot produce all relevant results, because the primary data are images that exist as graphical objects. We have developed a unique knowledge base (FlyExpress) to facilitate visual mining of images from Drosophila melanogaster embryogenesis. By clicking on specific locations in pictures of fly embryos from different stages of development and different visual projections, users can produce a list of genes and publications instantly. In FlyExpress, each queryable embryo picture is a heat-map that captures the expression patterns of more than 4500 genes and more than 2600 published articles. In addition, one can view spatial patterns for particular genes over time as well as find other genes with similar expression patterns at a given developmental stage. Therefore, FlyExpress is a unique tool for mining spatiotemporal expression patterns in a format readily accessible to the scientific community. AVAILABILITY: http://www.flyexpress.net CONTACT: s.kumar@asu.edu.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsAudiovisual AidsData MiningDrosophila melanogasterDrosophila ProteinsEmbryonic DevelopmentGene Expression ProfilingDrosophila Proteins

Identifiers

PMID21994220
PMCPMC3223365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.