ArticleAmerican journal of physical anthropology2011
Comparative insights into the regulation of inflammation: levels and predictors of interleukin 6 and interleukin 10 in young adults in the Philippines.
Article in American journal of physical anthropology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Health among sexual and gender minority people affected by armed conflict and forced displacement: Call for a biocultural and minority stress framework.Social science & medicine (1982) · 2026Review
- Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Maternal serum cytokine levels and risk of bipolar disorder.Brain, behavior, and immunity · 2017Article
- No association between blood telomere length and longitudinally assessed diet or adiposity in a young adult Filipino population.European journal of nutrition · 2017Article
- Depressive symptoms are not associated with inflammation in younger and older adults in the Philippines.Evolution, medicine, and public health · 2013Article
- Cytokines and chemokines as biomarkers of community-acquired bacterial infection.Mediators of inflammation · 2013Article
- Early environments and the ecology of inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Inflammatory profiles in the non-pregnant state predict offspring birth weight at Cebu: evidence for inter-generational effects of low grade inflammation.Annals of human biology · 2012Article
- A highly sensitive immunoassay for interleukin-6 in dried blood spots.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Inflammation is a central part of innate immunity, but its role in anti-pathogen defenses has been overshadowed by recent interest in the contribution of inflammation to a wide range of chronic degenerative diseases. Current research on chronic inflammation is conducted primarily in affluent populations with low levels of infectious disease; comparative research in different ecological settings is needed to advance understandings of the causes and consequences of variation in the regulation of inflammation. This article investigates the levels and predictors of interleukin-6 (IL-6) and interleukin-10 (IL-10)-two cytokines important to the regulation of inflammation-in a large, population-based study in the Philippines. Concentrations of IL-6 and IL-10 were determined in N = 1,569 healthy young adults (20-22 years) in Metro Cebu, Philippines. IL-6 and IL-10 concentrations were positively correlated, and body mass index and symptoms of infectious disease were both associated with higher concentrations of IL-6 and IL-10. Median concentrations of IL-6 (1.0 pg/mL) and IL-10 (7.56 pg/mL) were substantially lower and higher, respectively, than levels reported for other populations based on a systematic review of prior research. This study contributes to a growing body of research in human ecological immunology, and suggests that there may be substantial population differences in the regulation of inflammation that has implications for the association between inflammation and disease.
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