Trial reportPsychopharmacology2012
fMRI of the brain's response to stimuli experimentally paired with alcohol intoxication.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Brain network dysfunctions in addiction: a meta-analysis of resting-state functional connectivity.Translational psychiatry · 2022Pooled it
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults.Psychopharmacology · 2015Trial
- Taste matters: lessons learned in translating a conditioned drug cue reactivity paradigm from rodents to humans.Frontiers in psychology · 2026Article
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- Brain activation to cannabis- and alcohol-related words in alcohol use disorder.Psychiatry research. Neuroimaging · 2019Article
- Evidence for incentive salience sensitization as a pathway to alcohol use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future.Neuroscience and biobehavioral reviews · 2019Review
- Pairing neutral cues with alcohol intoxication: new findings in executive and attention networks.Psychopharmacology · 2018Article
- Neural responses to cues paired with methamphetamine in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- GABAPsychopharmacology · 2018Review
- Development, Initial Testing and Challenges of an Ecologically Valid Reward Prediction Error FMRI Task for Alcoholism.Alcohol and alcoholism (Oxford, Oxfordshire) · 2017Article
- Externalizing personality traits, empathy, and gray matter volume in healthy young drinkers.Psychiatry research. Neuroimaging · 2016Article
- Associations between regional brain physiology and trait impulsivity, motor inhibition, and impaired control over drinking.Psychiatry research · 2015Article
- How acute and chronic alcohol consumption affects brain networks: insights from multimodal neuroimaging.Alcoholism, clinical and experimental research · 2012Review
- Correlation between Ventromedial Prefrontal Cortex Activation to Food Aromas and Cue-driven Eating: An fMRI Study.Chemosensory perception · 2012Article
- A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration.Alcohol and alcoholism (Oxford, Oxfordshire)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleIndividuals learn associations between alcohol's sensory properties and intoxication, with such conditioned stimuli (CS) becoming involved in craving and relapse. However, these CS also carry idiosyncratic associations.
objectivesThis study aimed to test brain responses to novel CS conditioned with alcohol intoxication.
methodsFourteen heavy drinkers (age 24.9 ± 3.2) performed a reaction time task with embedded novel geometric CS and were told only that the task was to measure alcohol's effect on speed. Rapid intravenous alcohol infusion (the unconditioned stimulus; UCS) began with the appearance of a CS+, using pharmacokinetic modeling to increment breath alcohol by ~18 mg% in 200 s per each of six CS-UCS pairings. Placebo-saline infusion with CS- used the same infusion parameters in same-day randomized/counterbalanced sessions. The next morning subjects, connected to inactive intravenous pumps, underwent functional magnetic resonance imaging (fMRI) of the same task with mixed brief presentations of CS+, CS-, and irrelevant CS and were told that alcohol could be infused at any time during imaging.
resultsCS- responses were significantly greater than those of CS+ in medial frontal cortex. Notably, CS+ responses were negative, suggesting reduced neural activity. Negative activity was most pronounced in early scans, extinguishing with time. As subjects were told that alcohol could be administered in fMRI, a CS+ without alcohol is similar to a negative prediction error, with associated reduced frontal activity during withheld reward.
conclusionsNovel stimuli relatively free of demand characteristics can be classically conditioned to intermittent brain exposure of even low alcohol concentrations, permitting imaging studies of conditioned alcohol expectancies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.