ArticleNature2011
Self-replication of information-bearing nanoscale patterns.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- An enzyme-based approach for highly efficient self-replication of DNA origami dimers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Single-Molecule Electrical Conductance in Z-form DNA:RNA.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Design principles, growth laws, and competition of minimal autocatalysts.Communications chemistry · 2024Article
- Signal amplified colorimetric nucleic acid detection based on autocatalytic hairpin assembly.RSC advances · 2024Article
- Recent Advances in DNA Origami-Engineered Nanomaterials and Applications.Chemical reviews · 2023Review
- DNA and the origins of life in micaceous clay.Biophysical journal · 2022Article
- The nonequilibrium cost of accurate information processing.Nature communications · 2022Article
- Direct visualization of floppy two-dimensional DNA origami using cryogenic electron microscopy.iScience · 2022Article
- Mutations in artificial self-replicating tiles: A step toward Darwinian evolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Litters of self-replicating origami cross-tiles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nonequilibrium correlations in minimal dynamical models of polymer copying.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Hidden geometries in networks arising from cooperative self-assembly.Scientific reports · 2018Article
- Exponential growth and selection in self-replicating materials from DNA origami rafts.Nature materials · 2017Article
- Self-replication: Nanostructure evolution.Nature materials · 2017Article
- Spontaneous emergence of catalytic cycles with colloidal spheres.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Physical determinants of the self-replication of protein fibrils.Nature physics · 2016Article
- Conformational gating of DNA conductance.Nature communications · 2015Article
- Artificial Molecular Machines.Chemical reviews · 2015Review
- Self-replication of DNA rings.Nature nanotechnology · 2015Article
- Multifarious assembly mixtures: systems allowing retrieval of diverse stored structures.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
DNA molecules provide what is probably the most iconic example of self-replication--the ability of a system to replicate, or make copies of, itself. In living cells the process is mediated by enzymes and occurs autonomously, with the number of replicas increasing exponentially over time without the need for external manipulation. Self-replication has also been implemented with synthetic systems, including RNA enzymes designed to undergo self-sustained exponential amplification. An exciting next step would be to use self-replication in materials fabrication, which requires robust and general systems capable of copying and amplifying functional materials or structures. Here we report a first development in this direction, using DNA tile motifs that can recognize and bind complementary tiles in a pre-programmed fashion. We first design tile motifs so they form a seven-tile seed sequence; then use the seeds to instruct the formation of a first generation of complementary seven-tile daughter sequences; and finally use the daughters to instruct the formation of seven-tile granddaughter sequences that are identical to the initial seed sequences. Considering that DNA is a functional material that can organize itself and other molecules into useful structures, our findings raise the tantalizing prospect that we may one day be able to realize self-replicating materials with various patterns or useful functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.