Evidence map›Paper›PMID 21993562›Full record

SynthesisThe Journal of investigative dermatology2012

Meta-analysis combining new and existing data sets confirms that the TERT-CLPTM1L locus influences melanoma risk.

Matthew H Law, Grant W Montgomery, Kevin M Brown, Nicholas G Martin, Graham J Mann, Nicholas K Hayward, Stuart MacGregor, Q-MEGA and AMFS Investigators

Open access · bronzeAbstract readLetterMeta-Analysis
In one paragraph

Synthesis in The Journal of investigative dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.The Journal of investigative dermatology · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Association of CRR9 locus with elevated risk of squamous cell carcinoma and basal cell carcinoma.International journal of clinical and experimental medicine · 2015
    Article
  15. Article
  16. Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014
    Article
  17. Correlation of CLPTM1L polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Matthew H Law
Grant W Montgomery
Kevin M Brown
Nicholas G Martin
Graham J Mann
Nicholas K Hayward
Stuart MacGregor
Q-MEGA and AMFS Investigators
QIMR Berghofer Medical Research Institute · AUNational Cancer Institute · USThe University of Sydney · AU

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Genetic Epidermiology of MelanomaR01CA083115 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BISHOP, DAVID TIMOTHY, ELDER, DAVID ERIC · 2001 to 2017
$13.0M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Transdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9M
BIOCHEMICAL MARKERS IN THE NURSES HEALTH STUDY COHORTU01CA049449 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HANKINSON, SUSAN E · 1995 to 2013
$5.4M
Pathways from genotype and environment to melanomaR01CA088363 · NCI · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI HAYWARD, NICHOLAS K · 2001 to 2012
$2.4M
Genetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5M
Cohort Study of Genetic Susceptibility to Cutaneous Malignant MelanomaR01CA122838 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAN, JIALI · 2008 to 2010
$1.4M
Statistical Methods for Gene Environment Interactions In Lung CancerR01CA133996 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2009
$790k
NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA083115NCI NIH HHS R01 CA088363NCI NIH HHS R01 CA100264NCI NIH HHS R01 CA122838NCI NIH HHS R01 CA133996NCI NIH HHS U01 CA049449NCI NIH HHS U19 CA148127Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Polymorphism, Single NucleotideGenome-Wide Association StudyHumansMelanomaMembrane ProteinsNeoplasm ProteinsRiskSkin NeoplasmsTelomeraseCLPTM1L protein, humanMembrane ProteinsNeoplasm ProteinsTelomeraseTERT protein, human

Identifiers

PMID21993562
PMCPMC3258346
OpenAlexW2035434596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.