ArticleProceedings. Biological sciences2012
Genome-wide polymorphisms show unexpected targets of natural selection.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Signals of Natural Selection across Regions of Low Recombination in Wild Populations of the Purple Sea Urchin, Strongylocentrotus purpuratus.Genome biology and evolution · 2026Article
- Biological Mechanisms for Allen's Rule: DNA Methylation as Mediator of the Association Between In Utero Exposure to Environmental Heat and Tibial Growth in Childhood.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Selection Over Small and Large Spatial Scales in the Face of High Gene Flow.Molecular ecology · 2025Article
- Assessing Mechanisms of Potential Local Adaptation Through a Seascape Genomic Approach in a Marine Gastropod, Littoraria flava.Genome biology and evolution · 2024Article
- Population-specific vulnerability to ocean change in a multistressor environment.Science advances · 2023Article
- Eco-evolutionary consequences of habitat warming and fragmentation in communities.Biological reviews of the Cambridge Philosophical Society · 2021Article
- Population Genomic Analyses of the Sea Urchin Echinometra sp. EZ across an Extreme Environmental Gradient.Genome biology and evolution · 2020Article
- Little evidence of adaptation potential to ocean acidification in sea urchins living in "Future Ocean" conditions at a COEcology and evolution · 2019Article
- Concordant Changes in Gene Expression and Nucleotides Underlie Independent Adaptation to Hydrogen-Sulfide-Rich Environments.Genome biology and evolution · 2018Article
- Persistent and plastic effects of temperature on DNA methylation across the genome of threespine stickleback (Proceedings. Biological sciences · 2017Article
- Genome-wide signals of positive selection in strongylocentrotid sea urchins.BMC genomics · 2017Article
- Highly localized divergence within supergenes in Atlantic cod (Gadus morhua) within the Gulf of Maine.BMC genomics · 2017Article
- Article
- Perturbation of gut bacteria induces a coordinated cellular immune response in the purple sea urchin larva.Immunology and cell biology · 2016Article
- The Three Domains of Conservation Genetics: Case Histories from Hawaiian Waters.The Journal of heredity · 2016Review
- Evolution and population genomics of the Lyme borreliosis pathogen, Borrelia burgdorferi.Trends in genetics : TIG · 2015Review
- The impact of gene expression variation on the robustness and evolvability of a developmental gene regulatory network.PLoS biology · 2013Article
- Going where traditional markers have not gone before: utility of and promise for RAD sequencing in marine invertebrate phylogeography and population genomics.Molecular ecology · 2013Article
- Genetics of gene expression responses to temperature stress in a sea urchin gene network.Molecular ecology · 2012Article
- Variation at innate immunity Toll-like receptor genes in a bottlenecked population of a New Zealand robin.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural selection can act on all the expressed genes of an individual, leaving signatures of genetic differentiation or diversity at many loci across the genome. New power to assay these genome-wide effects of selection comes from associating multi-locus patterns of polymorphism with gene expression and function. Here, we performed one of the first genome-wide surveys in a marine species, comparing purple sea urchins, Strongylocentrotus purpuratus, from two distant locations along the species' wide latitudinal range. We examined 9112 polymorphic loci from upstream non-coding and coding regions of genes for signatures of selection with respect to gene function and tissue- and ontogenetic gene expression. We found that genetic differentiation (F(ST)) varied significantly across functional gene classes. The strongest enrichment occurred in the upstream regions of E3 ligase genes, enzymes known to regulate protein abundance during development and environmental stress. We found enrichment for high heterozygosity in genes directly involved in immune response, particularly NALP genes, which mediate pro-inflammatory signals during bacterial infection. We also found higher heterozygosity in immune genes in the southern population, where disease incidence and pathogen diversity are greater. Similar to the major histocompatibility complex in mammals, balancing selection may enhance genetic diversity in the innate immune system genes of this invertebrate. Overall, our results show that how genome-wide polymorphism data coupled with growing databases on gene function and expression can combine to detect otherwise hidden signals of selection in natural populations.
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