ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.PloS one · 2012Trial
- Neural stem cells as potential mediators of prenatal dietary stress through epigenetic mechanisms.Stem cell reports · 2026Article
- Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings With Human Correlation.Gastroenterology · 2026Article
- Disrupted maternal care alters neural-microglia interactions in the primate paralaminar (PL) nucleus of the amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression.International journal of molecular sciences · 2025Review
- Early Life Adversity, Microbiome, and Inflammatory Responses.Biomolecules · 2024Review
- Modulation of gut microbiota composition due to early weaning stress induces depressive behavior during the juvenile period in mice.Animal microbiome · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Biomarkers of stress resilience: A review.Neuroscience applied · 2024Article
- Father's care uniquely influences male neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Variation along P2RX7 interacts with early traumas on severity of anxiety suggesting a role for neuroinflammation.Scientific reports · 2023Article
- Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood.Advances in experimental medicine and biology · 2023Review
- Early life stress impairs synaptic pruning in the developing hippocampus.Brain, behavior, and immunity · 2023Article
- Oxytocin and microglia in the development of social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Microglial synaptic pruning on axon initial segment spines of dentate granule cells: Sexually dimorphic effects of early-life stress and consequences for adult fear response.Journal of neuroendocrinology · 2021Article
- Early Life Stress Exacerbates Outcome after Traumatic Brain Injury.Journal of neurotrauma · 2021Article
- Article
- From early adversities to immune activation in psychiatric disorders: the role of the sympathetic nervous system.Clinical and experimental immunology · 2019Review
- Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation.Frontiers in psychiatry · 2019Review
- Early life stress perturbs the function of microglia in the developing rodent brain: New insights and future challenges.Brain, behavior, and immunity · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Childhood maltreatment represents a major risk factor for the development of numerous childhood psychopathologies that in many cases linger as chronic mental illnesses in adulthood. Exposing rodents or non-human primates to early life stress increases anxiety-like behaviors and impairs cognitive function in adulthood, suggesting that animal models may provide important insights into parallel developmental processes in humans. Using an unbiased genomic screen, we found that expression of lipopolysaccharide binding protein (LBP), a member of the innate immune system, is dramatically decreased in the hippocampus of pups exposed to early life stress. LBP levels peak in the normally developing hippocampus at a period of intense synaptic pruning, during which LBP is colocalized with the synaptic marker PSD95 and is found in close proximity to processes of microglia cells. Expression of LBP declines to low levels seen in adulthood at around postnatal day 30. Importantly, 30-day-old LBP knockout (k.o.) mice show increased spine density and abnormal spine morphology, suggesting that peak levels of LBP during the second and third weeks of life are necessary for normal synaptic pruning in the hippocampus. Finally, LBP k.o. mice show impaired hippocampal-dependent memory and increased anxiety-like behaviors in a manner that resembles that seen in animals exposed to early life stress. These findings describe a novel role for LBP in normal hippocampal development and raise the possibility that at least some of the behavioral sequelae of early life stress are mediated by reduced expression of LBP during a critical period of neurodevelopment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.