Evidence map›Paper›PMID 21993193›Full record

SynthesisBiological psychiatry2012

Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia.

Stephan F Taylor, Jian Kang, Inga S Brege, Ivy F Tso, Avinash Hosanagar, Timothy D Johnson

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  6. Pooled it
  7. Trial
  8. Oxytocin increases eye gaze in schizophrenia.Schizophrenia research · 2019
    Trial
  9. Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
    Trial
  10. Abnormal GABAergic function and negative affect in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Trial
  11. Trial
  12. Article
  13. Article
  14. Review
  15. Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Stephan F TaylorDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109-2700, USA. sftaylor@umich.edu
Jian Kang
Inga S Brege
Ivy F Tso
Avinash Hosanagar
Timothy D Johnson

Funding

GABA Modulation and Negative Affect in PsychosisR21MH086701 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAYLOR, STEPHAN F · 2009 to 2010
$425k
NIMH NIH HHS MH086701NIMH NIH HHS R21 MH086701
6 · The paper itself

Abstract

backgroundNeuroimaging studies of emotion in schizophrenia have reported abnormalities in amygdala and other regions, although divergent results and heterogeneous paradigms complicate conclusions from single experiments. To identify more consistent patterns of dysfunction, a meta-analysis of functional imaging studies of emotion was undertaken.

methodsSearching Medline and PsycINFO databases through January 2011, 88 potential articles were identified, of which 26 met inclusion criteria, comprising 450 patients with schizophrenia and 422 healthy comparison subjects. Contrasts were selected to include emotion perception and emotion experience. Foci from individual studies were subjected to a voxelwise meta-analysis using multilevel kernel density analysis.

resultsFor emotional experience, comparison subjects showed greater activation in the left occipital pole. For emotional perception, schizophrenia subjects showed reduced activation in bilateral amygdala, visual processing areas, anterior cingulate cortex, dorsolateral frontal cortex, medial frontal cortex, and subcortical structures. Schizophrenia subjects showed greater activation in the cuneus, parietal lobule, precentral gyrus, and superior temporal gyrus. Combining across studies and eliminating studies that did not balance on effort and stimulus complexity eliminated most differences in visual processing regions as well as most areas where schizophrenia subjects showed a greater signal. Reduced reactivity of the amygdala appeared primarily in implicit studies of emotion, whereas deficits in anterior cingulate cortex activity appeared throughout all contrasts.

conclusionsProcessing emotional stimuli, schizophrenia patients show reduced activation in areas engaged by emotional stimuli, although in some conditions, schizophrenia patients exhibit increased activation in areas outside those traditionally associated with emotion, possibly representing compensatory processing.

Indexed as

Schizophrenic PsychologyAdolescentAdultBrainEmotionsFemaleFunctional NeuroimagingHumansMalePerceptionSchizophrenia

Identifiers

PMID21993193
PMCPMC3237865

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.