Evidence map›Paper›PMID 21993163›Full record

ArticleAging clinical and experimental research2011

Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function.

Thomas W Buford, Matthew B Cooke, Brian D Shelmadine, Geoffrey M Hudson, Liz L Redd, Darryn S Willoughby

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Frontiers in medicine · 2019
    Article
  4. Review
  5. The level of FoxO1 and IL-15 in skeletal muscle, serum and synovial fluid in people with knee osteoarthritis: a case control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Thomas W BufordDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL 32607, USA. tbuford@aging.ufl.edu
Matthew B Cooke
Brian D Shelmadine
Geoffrey M Hudson
Liz L Redd
Darryn S Willoughby
Baylor University · USUniversity of Florida · USUniversity of Queensland · AUUniversity of Southern Mississippi · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
UF Clinical and Translational Science AwardKL2RR029888 · NCRR · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2009 to 2011
$1.8M
NCRR NIH HHS 1KL2RR029888-01NCRR NIH HHS KL2 RR029888NIA NIH HHS 1P30AG028740NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

BACKGROUND AND

aimsAging is associated with significant losses of skeletal muscle mass and function. Numerous biochemical molecules have been implicated in the development of these age-related changes, however evidence from human models is sparse. Assessment of transcript expression is useful as it requires minimal tissue and may potentially be used in clinical trials. This study aimed to compare mRNA expression of proteolytic genes in skeletal muscle of young (18-35 yrs) and older (55-75 yrs) men.

methodsMuscle tissue was obtained from young (n=14, 21.35±1.03 yrs) and older (n=13, 63.85±1.83 yrs) men using percutaneous biopsy, and transcript expression was quantified using real-time polymerase chain reaction. Lower limb muscle mass was assessed using DEXA while concentric peak torque (PT) and power were assessed via isokinetic dynamometer. When age-related differences in mRNA expression were observed, Pearson correlation coefficients were obtained to examine the relationship of transcripts to muscle mass and function.

resultsOlder muscle contained significantly more transcript for Forkhead Box O 1 (FoxO1, p=0.001), Inhibitor of DNA binding 1 (ID1, p=0.009), and Inhibitor of DNA Binding 3 (ID3, p=0.043) than young muscle. FoxO1 was significantly correlated with lean mass (R=-0.44, p=0.023) and PT (R=-0.40, p=0.046) while ID3 was significantly correlated with PT (R=-0.58, p=0.001) and power (R=-0.65, p<0.001). Moreover, ID1 was significantly correlated with all assessed measures of muscle function - mass (R=-0.39, p=0.046), PT (R=-0.53, p=0.005), and power (R=-0.520, p=0.005).

conclusionThese data suggest that FoxO1, ID1, and ID3 are potentially useful as clinical biomarkers of age-related muscle atrophy and dysfunction.

Indexed as

Gene Expression RegulationAgingBody WeightForkhead Box Protein O1Forkhead Transcription FactorsHumansInhibitor of Differentiation Protein 1Inhibitor of Differentiation ProteinsMaleMiddle AgedMuscle, SkeletalMuscle StrengthNeoplasm ProteinsPeptide HydrolasesRNA, MessengerYoung AdultForkhead Box Protein O1Forkhead Transcription FactorsFOXO1 protein, humanID1 protein, humanID3 protein, humanInhibitor of Differentiation Protein 1Inhibitor of Differentiation ProteinsNeoplasm ProteinsPeptide HydrolasesRNA, Messenger

Identifiers

PMID21993163
PMCPMC3683395
OpenAlexW2020939484

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.