ArticleJournal of the Royal Society, Interface2012
Influence of strontium for calcium substitution in bioactive glasses on degradation, ion release and apatite formation.
Article in Journal of the Royal Society, Interface, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 190 citations in OpenAlex.
- Randomized investigation of the bioavailability of fluoride in saliva after administration of sodium fluoride, amine fluoride and fluoride containing bioactive glass dentifrices.BMC oral health · 2019Trial
- Microhardness and Chemical Composition of Glass Ionomer and Glass Hybrid Cements Modified with Experimental Bioactive Glasses.Acta stomatologica Croatica · 2026Article
- Antibacterial activity and physicochemical properties of light-curable fluoride varnishes containing strontium phosphate-based glass.Clinical oral investigations · 2025Article
- Three-dimensional-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with enhanced angiogenic and osteogenic properties.Regenerative biomaterials · 2025Article
- The Effect of Irrigation Solutions on the Setting Time, Solubility, and pH of Three Types of Premixed Bioceramic-Based Root Canal Sealers.International journal of dentistry · 2025Article
- Advances in biomaterials for osteonecrosis treatment.Frontiers in pharmacology · 2025Review
- Three-dimensional-printed triply periodic minimal surface scaffolds via digital light processing for enhanced osteogenesis.Regenerative biomaterials · 2025Article
- Structural and Dynamical Effects of the CaO/SrO Substitution in Bioactive Glasses.Molecules (Basel, Switzerland) · 2024Article
- Strontium and Zinc Co-Doped Mesoporous Bioactive Glass Nanoparticles for Potential Use in Bone Tissue Engineering Applications.Nanomaterials (Basel, Switzerland) · 2024Article
- Chitosan and Sodium Hyaluronate Hydrogels Supplemented with Bioglass for Bone Tissue Engineering.Gels (Basel, Switzerland) · 2024Article
- Synthesis of a Calcium Silicate Cement Containing a Calcinated Strontium Silicate Phase.International journal of dentistry · 2024Article
- Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration.Materials (Basel, Switzerland) · 2023Review
- Enhancing bone tissue engineering with 3D-Printed polycaprolactone scaffolds integrated with tragacanth gum/bioactive glass.Materials today. Bio · 2023Article
- Article
- Novel Bioactive Glass/Graphene Oxide-Coated Surgical Sutures for Soft Tissue Regeneration.ACS omega · 2023Article
- Multifunctional Zn and Ag co-doped bioactive glass nanoparticles for bone therapeutic and regeneration.Scientific reports · 2023Article
- 3D Printed Osteoblast-Alginate/Collagen Hydrogels Promote Survival, Proliferation and Mineralization at Low Doses of Strontium Calcium Polyphosphate.Pharmaceutics · 2022Article
- Can strontium replace calcium in bioactive materials for dental applications?Journal of biomedical materials research. Part A · 2022Article
- Surface Modification of 3D-Printed PCL/BG Composite Scaffolds via Mussel-Inspired Polydopamine and Effective Antibacterial Coatings for Biomedical Applications.Materials (Basel, Switzerland) · 2022Article
- Nanofibrous Hydrogel Nanocomposite Based on Strontium-Doped Bioglass Nanofibers for Bone Tissue Engineering Applications.Biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive glasses are able to bond to bone through the formation of hydroxy-carbonate apatite in body fluids while strontium (Sr)-releasing bioactive glasses are of interest for patients suffering from osteoporosis, as Sr was shown to increase bone formation both in vitro and in vivo. A melt-derived glass series (SiO(2)-P(2)O(5)-CaO-Na(2)O) with 0-100% of calcium (Ca) replaced by Sr on a molar base was prepared. pH change, ion release and apatite formation during immersion of glass powder in simulated body fluid and Tris buffer at 37°C over up to 8 h were investigated and showed that substituting Sr for Ca increased glass dissolution and ion release, an effect owing to an expansion of the glass network caused by the larger ionic radius of Sr ions compared with Ca. Sr release increased linearly with Sr substitution, and apatite formation was enhanced significantly in the fully Sr-substituted glass, which allowed for enhanced osteoblast attachment as well as proliferation and control of osteoblast and osteoclast activity as shown previously. Studying the composition-structure-property relationship in bioactive glasses enables us to successfully design next-generation biomaterials that combine the bone regenerative properties of bioactive glasses with the release of therapeutically active Sr ions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.