ArticleDiabetologia1990
Kidney IGF-I mRNA in initial renal hypertrophy in experimental diabetes in rats.
Article in Diabetologia, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 96 citations in OpenAlex.
- Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.The Journal of clinical endocrinology and metabolism · 2009Trial
- Human umbilical cord mesenchymal stem cells attenuate diabetic nephropathy through the IGF1R-CHK2-p53 signalling axis in male rats with type 2 diabetes mellitus.Journal of Zhejiang University. Science. B · 2024Article
- d-allulose protects against diabetic nephropathy progression in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes.PloS one · 2022Article
- Epigenetic analyses of the insulin-like growth factor binding protein 1 gene in type 1 diabetes and diabetic nephropathy.Clinical epigenetics · 2014Article
- IGFBP2 is a biomarker for predicting longitudinal deterioration in renal function in type 2 diabetes.Endocrine connections · 2012Article
- Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes.International journal of experimental pathology · 2012Article
- The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2011Article
- Identification of compounds that inhibit IGF-I signaling in hyperglycemia.Experimental diabetes research · 2009Article
- What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?Diabetologia · 2008Review
- Renal carcinogenesis in models of diabetes in rats: metabolic changes are closely related to neoplastic development.Diabetologia · 2007Article
- Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.Journal of endocrinological investigation · 1999Review
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- Renal growth during pregnancy in insulin-dependent diabetic women. A prospective study of renal volume and clinical variables.Acta diabetologica · 1995Article
- The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels.Endocrine · 1995Article
- Cellular and molecular pathomechanisms of diabetic nephropathy.The Clinical investigator · 1993Review
- Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Transient increase in renal insulin-like growth factor binding proteins during initial kidney hypertrophy in experimental diabetes in rats.Diabetologia · 1992Article
- Distribution of IGF-I mRNA and IGF-I binding sites in the rat kidney.Histochemistry · 1992Article
- Effect of insulin-like growth factor I infusion on renal hypertrophy in experimental diabetes mellitus in rats.Diabetologia · 1991Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently been demonstrated that immunoassayable kidney insulin-like growth factor I concentration increases 24-48 h after induction of diabetes, preceding the initial renal hypertrophy. To elucidate whether this increase is due to increased local production we studied rat kidney insulin-like growth factor I gene expression during the first four days after induction of streptozotocin diabetes. Eighteen hours after injection with streptozotocin the diabetic animals were divided into two groups, one of which was treated with insulin, and daily for four days animals from each group were taken out for investigation. After four days the wet kidney weight had increased from baseline by 20% (from 687 +/- 23 to 827 +/- 6 mg (mean +/- SEM), p less than 0.01) in the untreated diabetic group, while no significant increase occurred in the insulin-treated group (687 +/- 23 vs 732 +/- 21 mg, NS). Kidney insulin-like growth factor I increased rapidly from baseline, the rise amounting to 52% after 48 h (from 271 +/- 11 to 411 +/- 32 ng/g, p less than 0.01) with a decline to control level on day four in the untreated diabetic group. Kidney insulin-like growth factor I remained unchanged in the insulin-treated diabetic group. Insulin-like growth factor I mRNA was measured by solution-hybridization assay. No differences were found in kidney insulin-like growth factor I mRNA between the two diabetic groups over the study period, while in liver, insulin-like growth factor I mRNA tended to be lower on day four in diabetic rats when compared to insulin-treated rats (p = 0.07).(ABSTRACT TRUNCATED AT 250 WORDS)
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