ArticleGut pathogens2011
Comparative analyses of Campylobacter concisus strains reveal the genome of the reference strain BAA-1457 is not representative of the species.
Article in Gut pathogens, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Pathogenomics of EmergingClinical microbiology reviews · 2019Review
- Nonulosonic acids contribute to the pathogenicity of the oral bacteriumInterface focus · 2019Review
- Motility and biofilm formation of the emerging gastrointestinal pathogen Campylobacter concisus differs under microaerophilic and anaerobic environments.Gut microbes · 2019Article
- Site-directed mutagenesis of Campylobacter concisus respiratory genes provides insight into the pathogen's growth requirements.Scientific reports · 2018Article
- Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential.Emerging microbes & infections · 2018Article
- The Clinical Importance ofFrontiers in cellular and infection microbiology · 2018Review
- Complete Genome Sequence ofGenome announcements · 2017Article
- Tannerella forsythia strains display different cell-surface nonulosonic acids: biosynthetic pathway characterization and first insight into biological implications.Glycobiology · 2017Article
- Campylobacter ureolyticus: a portrait of the pathogen.Virulence · 2014Review
- The renaissance of bacillosamine and its derivatives: pathway characterization and implications in pathogenicity.Biochemistry · 2014Review
- Comparative genomics of Campylobacter concisus isolates reveals genetic diversity and provides insights into disease association.BMC genomics · 2013Article
- Detection of Campylobacter species and Arcobacter butzleri in stool samples by use of real-time multiplex PCR.Journal of clinical microbiology · 2013Article
- Investigation of motility and biofilm formation by intestinal Campylobacter concisus strains.Gut pathogens · 2012Article
- Article
- Campylobacter concisus - A new player in intestinal disease.Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have shown that significant genotypic heterogeneity exists among Campylobacter concisus strains. Recently, the genome of C. concisus UNSWCD, isolated from a patient with Crohn's disease, was sequenced.
resultsIn this study, comparative analyses were performed between strain UNSWCD and BAA-1457, isolated from a patient with acute gastroenteritis. Searches between C. concisus UNSWCD and BAA-1457 showed that 76% of genes were homologues, whereas those between C. jejuni strains showed 90-91% to be homologues, indicating substantial variation exists within these two C. concisus genomes. More specific bidirectional homology searches identified 1593 genes that are shared between these strains, and 115 and 281 genes unique to UNSWCD and BAA-1457, respectively. Significantly, differences in the type of flagellin glycosylation pathways between the two strains were identified and confirmed by PCR. The protein profiles of UNSWCD, BAA-1457 and a further six strains of C. concisus were compared and analyzed bioinformatically, and this differentiated the strains into four clades. BAA-1457 was found to be highly divergent (average similarity: 56.8%) from the other seven strains (mean average similarity ± standard deviation: 64.7 ± 1.7%). Furthermore, searches for homologues of the 1593 proteins found to be common between UNSWCD and BAA-1457 were conducted against all available bacterial genomes, and 18 proteins were found to be unique to C. concisus, of which 6 were predicted to be secreted, and may represent good markers for detection of this species.
conclusionsThis study has elucidated several features that may be responsible for the heterogeneity that exists among C. concisus strains, and has determined that the strain BAA-1457 is genetically atypical to other C. concisus strains and is not a good candidate reference strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.