ArticleDiagnostic pathology2011
Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin.
Article in Diagnostic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Overexpression of osteopontin promotes cell proliferation and migration in human nasopharyngeal carcinoma and is associated with poor prognosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Article
- Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases.Asian Pacific journal of cancer prevention : APJCP · 2016Article
- Osteopontin Expression in Patients with Hepatolith.The Indian journal of surgery · 2015Article
- Relationship between osteopontin and β-catenin immunohistochemical expression and prognostic parameters of colorectal carcinoma.International journal of clinical and experimental pathology · 2015Article
- OPN and αvβ3 expression are predictors of disease severity and worse prognosis in hepatocellular carcinoma.PloS one · 2014Article
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4 authors.
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Abstract
backgroundAmpullary cancer (AC) was classified as pancreatobiliary, intestinal, or other subtype based on the expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20). We aimed to explore the association of AC subtype with patient prognosis.
methodsThe relationship of AC subtype and expression of Osteopontin (OPN) with the prognosis of 120 AC patients after pancreaticoduodenectomy was investigated.
resultsThe patients had pancreatobiliary (CK7+/CK20-, n = 24, 20%), intestinal (CK7-/CK20+, n = 29, 24.2%) or other (CK7+/CK20+ or CK7-/CK20-, n = 67, 55.8%) subtypes of AC, and their median survival times were 23 ± 4.2, 38 ± 2.8 and 64 ± 16.8 months, respectively. The survival times of 64 OPN- patients (53.3%) and 56 OPN+ patients (46.7%) were 69 ± 18.4 and 36 ± 1.3 months, respectively. There was no significant effect of AC subtype on survival of OPN- patients. For OPN+ patients, those with pancreatobiliary AC had a shorter survival time (22 ± 6.6 months) than those with intestinal AC (37 ± 1.4 months, p = 0.041), and other AC subtype (36 ± 0.9 months, p = 0.010); intestinal and other AC subtypes had similar survival times.
conclusionsThe prognosis of AC patients can be estimated based on immunohistochemical classification and OPN status.
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