Evidence map›Paper›PMID 21991976›Full record

ArticleThe New England journal of medicine2011

Induced immune tolerance for kidney transplantation.

John D Scandling, Stephan Busque, Judith A Shizuru, Edgar G Engleman, Samuel Strober

6 registry-linked trialsAbstract readLetter
In one paragraph

Article in The New England journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00319657 phase1 / phase2unknown statusnot on this map

Total Lymphoid Irradiation, Anti-Thymocyte Globulin and Purified Donor CD34+ and T-Cell Transfusion in HLA-Matched Living Donor Kidney Transplantation

TypeinterventionalSponsorStanford UniversityRan2004 to 2026Enrolled15ConditionsImmune ToleranceArmsHematopoietic cell transplantation, Total lymphoid irradiation
NCT01165762 phase1unknown statusnot on this map

Total Lymphoid Irradiation, Anti-Thymocyte Globulin and Purified Donor CD34+ and T-cell Transfusion in HLA Haplotype Match Living Donor Kidney Transplantation

TypeinterventionalSponsorEverett MeyerRan2010 to 2025Enrolled25ConditionsESRDArmsImmune Tolerance
NCT02176434 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease

TypeinterventionalSponsorUniversity of ZurichRan2015 to 2025Enrolled16ConditionsEnd Stage Renal DiseaseArmsKidney and hematopoietic stem cell transplantation, hematopoietic stem cell
NCT03292445 early_phase1unknown statusnot on this mapstarted 2017, after this paper: background citation

Induction of Immune Tolerance by Total Lymphoid Irradiation, Anti-Thymocyte Globulin and Purified Donor CD34+ and T Cell Transfusion in HLA Haplotype Matched Related and 3 Antigen HLA Matched Unrelated Living Donor Kidney Transplantation

TypeinterventionalSponsorSamuel StroberRan2017 to 2024Enrolled24ConditionsImmune ToleranceArmsImmune tolerance after kidney transplant, Donor blood stem cells and T cells
NCT03591302 phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Total Lymphoid Irradiation, Anti-Thymocyte Globulin and Purified Donor CD34+ and T-cell Transfusion to Withdraw Immunosuppressive Drugs From Recipients of a Previous HLA Matched Living Donor Kidney Transplantation .

TypeinterventionalSponsorStephan BusqueRan2024 to 2028Enrolled25ConditionsImmune ToleranceArmsHematopoietic cell transplantation, Total Lymphoid irradiation
NCT03943238 phase1recruitingnot on this mapstarted 2020, after this paper: background citation

Phase 1 Study of Total Lymphoid Irradiation, Total Body Irradiation, Anti-Thymocyte Globulin and Purified Donor CD34+, T-cell and Recipient T Regulatory Cell Transfusion in Human Leukocyte Antigen Mismatched Living Donor Kidney Transplantation

TypeinterventionalSponsorStanford UniversityRan2020 to 2029Enrolled22ConditionsLiving Donor Kidney TransplantationArmsInfusion of Donor Hematopoetic Stem Cells and Recipient Tregs
3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Preclinical and clinical studies on kidney allograft tolerance via hematopoietic chimerism.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. From Epithelium to Therapy: Transitional Cells in Lung Fibrosis.American journal of respiratory cell and molecular biology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Helical TomoTherapy Total Lymphoid Irradiation and Hematopoietic Cell Transplantation for Kidney Transplant Tolerance in Rhesus Macaques.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. New Approaches to Cryopreservation of Cells, Tissues, and Organs.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019
    Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

John D Scandling
Stephan Busque
Judith A Shizuru
Edgar G Engleman
Samuel Strober

Funding

TLI/ATG CONDTIONING: KIDNEY/BLOOD STEM CELL TRANSPLANTSP01HL075462 · NHLBI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G. · 2004 to 2020
$27.9M
Immunobiology of a novel human DAMP receptor, its murine homolog, & their ligandR01AI185024 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jiann-Jyh Lai · 2025 to 2026
$1.2M
NHLBI NIH HHS P01 HL075462NIAID NIH HHS R01 AI1085024NIAID NIH HHS R01 AI185024
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hematopoietic Stem Cell TransplantationImmune ToleranceT-LymphocytesAdultAntigens, CD34CD3 ComplexFemaleHematopoietic Stem CellsHumansImmunosuppression TherapyKidney TransplantationMaleMiddle AgedTransplantation ConditioningTransplantation ImmunologyTransplantation ToleranceAntigens, CD34CD3 Complex

Identifiers

PMID21991976
PMCPMC3334358

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.