ArticleBiomedical optics express2011
Field-portable reflection and transmission microscopy based on lensless holography.
Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed.
- Mobile phone microscopy for the diagnosis of soil-transmitted helminth infections: a proof-of-concept study.The American journal of tropical medicine and hygiene · 2013Trial
- A customizable digital holographic microscope.HardwareX · 2024Article
- Multi-Illumination Single-Holographic-Exposure Lensless Fresnel (MISHELF) Microscopy: Principles and Biomedical Applications.Sensors (Basel, Switzerland) · 2023Review
- Design, Calibration, and Application of a Robust, Cost-Effective, and High-Resolution Lensless Holographic Microscope.Sensors (Basel, Switzerland) · 2022Article
- Holographic virtual staining of individual biological cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet.Biomedical optics express · 2018Article
- Reflective lens-free imaging on high-density silicon microelectrode arrays for monitoring and evaluation ofBiomedical optics express · 2018Article
- Point-of-care mobile digital microscopy and deep learning for the detection of soil-transmitted helminths and Schistosoma haematobium.Global health action · 2017Article
- Compact, cost-effective and field-portable microscope prototype based on MISHELF microscopy.Scientific reports · 2017Article
- Compact Lens-less Digital Holographic Microscope for MEMS Inspection and Characterization.Journal of visualized experiments : JoVE · 2016Article
- Improved Tracking and Resolution of Bacteria in Holographic Microscopy Using Dye and Fluorescent Protein Labeling.Frontiers in chemistry · 2016Article
- Malaria Diagnosis Using a Mobile Phone Polarized Microscope.Scientific reports · 2015Article
- Automated cell viability assessment using a microfluidics based portable imaging flow analyzer.Biomicrofluidics · 2015Article
- Quantitative evaluation of a handheld light microscope for field diagnosis of soil-transmitted helminth infection.The American journal of tropical medicine and hygiene · 2014Article
- Detection of Kaposi's sarcoma associated herpesvirus nucleic acids using a smartphone accessory.Lab on a chip · 2014Article
- Computational imaging, sensing and diagnostics for global health applications.Current opinion in biotechnology · 2014Review
- Optical systems for point-of-care diagnostic instrumentation: analysis of imaging performance and cost.Annals of biomedical engineering · 2014Article
- 0.5 gigapixel microscopy using a flatbed scanner.Biomedical optics express · 2013Article
- Optical imaging techniques for point-of-care diagnostics.Lab on a chip · 2013Review
- On-chip biomedical imaging.IEEE reviews in biomedical engineering · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We demonstrate a lensfree dual-mode holographic microscope that can image specimens in both transmission and reflection geometries using in-line transmission and off-axis reflection holography, respectively. This field-portable dual-mode holographic microscope has a weight of ~200 g with dimensions of 15 x 5.5 x 5cm, where a laser source is powered by two batteries. Based on digital in-line holography, our transmission microscope achieves a sub-pixel lateral resolution of ≤2 µm over a wide field-of-view (FOV) of ~24 mm(2) due to its unit fringe magnification geometry. Despite its simplicity and ease of operation, in-line transmission geometry is not suitable to image dense or connected objects such as tissue slides since the reference beam gets distorted causing severe aberrations in reconstruction of such objects. To mitigate this challenge, on the same cost-effective and field-portable assembly we built a lensless reflection mode microscope based on digital off-axis holography where a beam-splitter is used to interfere a tilted reference wave with the reflected light from the object surface, creating an off-axis hologram of the specimens on a CMOS sensor-chip. As a result of the reduced space-bandwidth product of the off-axis geometry compared to its in-line counterpart, the imaging FOV of our reflection mode is reduced to ~9 mm(2), while still achieving a similar sub-pixel resolution of ≤2 µm. We tested the performance of this compact dual-mode microscopy unit by imaging a US-air force resolution test target, various micro-particles as well as a histopathology slide corresponding to skin tissue. Due to its compact, cost-effective, and lightweight design, this dual-mode lensless holographic microscope might especially be useful for field-use or for conducting microscopic analysis in resource-poor settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.