Evidence map›Paper›PMID 21991548›Full record

ArticleBiomedical optics express2011

Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat.

Justin Wanek, Pang-Yu Teng, John Albers, Norman P Blair, Mahnaz Shahidi

Open access · greenAbstract read
In one paragraph

Article in Biomedical optics express, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 27 citations in OpenAlex.

  1. Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026
    Article
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  17. A Model for Graded Retinal Ischemia in Rats.Translational vision science & technology · 2018
    Article
  18. Article
  19. Article
  20. Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Justin WanekDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago IL, 60612, USA.
Pang-Yu Teng
John Albers
Norman P Blair
Mahnaz Shahidi
University of Illinois Chicago · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCANANY, JAMES JASON · 1985 to 2025
$14.8M
Noninvasive Imaging of Chorioretinal Oxygen TensionR01EY017918 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHAHIDI, MAHNAZ · 2007 to 2022
$6.2M
NEI NIH HHS P30 EY001792NEI NIH HHS R01 EY017918
6 · The paper itself

Abstract

The metabolic function of inner retinal cells relies on the availability of nutrients and oxygen that are supplied by the retinal circulation. Assessment of retinal tissue vitality and function requires knowledge of both the rate of oxygen delivery and consumption. The purpose of the current study is to report a novel technique for assessment of the inner retinal metabolic rate of oxygen (MO(2)) by combined measurements of retinal blood flow and vascular oxygen tension (PO(2)) in rat. The application of this technology has the potential to broaden knowledge of retinal oxygen dynamics and advance understanding of disease pathophysiology.

Indexed as

(100.2960) Image analysis(170.2655) Functional monitoring and imaging(170.3880) Medical and biological imaging

Identifiers

PMID21991548
PMCPMC3184865
OpenAlexW2011769738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.