ArticlePloS one2011
Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
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- Differential Gene Expression and Immune Cell Infiltration in Patients with Steroid-induced Necrosis of the Femoral Head.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Thymus antibody-secreting cells: once forgotten but not lost.Frontiers in immunology · 2023Article
- Multimericity Amplifies the Synergy of BCR and TLR4 for B Cell Activation and Antibody Class Switching.Frontiers in immunology · 2022Article
- Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma.JCI insight · 2021Article
- Biochemical coordination of plasma cell genesis.Immunological reviews · 2021Review
- TLR2 deficiency promotes IgE and inhibits IgG1 class-switching following ovalbumin sensitization.Italian journal of pediatrics · 2021Article
- Urine stem cells are equipped to provide B cell survival signals.Stem cells (Dayton, Ohio) · 2021Article
- Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis.PloS one · 2019Article
- The Nod2 Agonist Muramyl Dipeptide Cooperates with the TLR4 Agonist Lipopolysaccharide to Enhance IgG2b Production in Mouse B Cells.Journal of immunology research · 2019Article
- Distinguishing naive- from memory-derived human B cells during acute responses.Clinical & translational immunology · 2019Article
- Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers.Frontiers in immunology · 2019Article
- Enhancing Protective Efficacy of Poultry Vaccines through Targeted Delivery of Antigens to Antigen-Presenting Cells.Vaccines · 2018Review
- Targeting CD40 enhances antibody- and CD8-mediated protection against respiratory syncytial virus infection.Scientific reports · 2018Article
- Induction and Subversion of Human Protective Immunity: Contrasting Influenza and Respiratory Syncytial Virus.Frontiers in immunology · 2018Review
- Article
- Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo.PloS one · 2017Article
- The Role of TLR4 on B Cell Activation and Anti-Journal of immunology research · 2016Review
- Toll-like receptor 2 activators modulate oral tolerance in mice.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Article
- Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity.The Journal of clinical investigation · 2015Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a classical dogma, pathogens are sensed (via recognition of Pathogen Associated Molecular Patterns (PAMPs)) by innate immune cells that in turn activate adaptive immune cells. However, recent data showed that TLRs (Toll Like Receptors), the most characterized class of Pattern Recognition Receptors, are also expressed by adaptive immune B cells. B cells play an important role in protective immunity essentially by differentiating into antibody-secreting cells (ASC). This differentiation requires at least two signals: the recognition of an antigen by the B cell specific receptor (BCR) and a T cell co-stimulatory signal provided mainly by CD154/CD40L acting on CD40. In order to better understand interactions of innate and adaptive B cell stimulatory signals, we evaluated the outcome of combinations of TLRs, BCR and/or CD40 stimulation. For this purpose, mouse spleen B cells were activated with synthetic TLR agonists, recombinant mouse CD40L and agonist anti-BCR antibodies. As expected, TLR agonists induced mouse B cell proliferation and activation or differentiation into ASC. Interestingly, addition of CD40 signal to TLR agonists stimulated either B cell proliferation and activation (TLR3, TLR4, and TLR9) or differentiation into ASC (TLR1/2, TLR2/6, TLR4 and TLR7). Addition of a BCR signal to CD40L and either TLR3 or TLR9 agonists did not induce differentiation into ASC, which could be interpreted as an entrance into the memory pathway. In conclusion, our results suggest that PAMPs synergize with signals from adaptive immunity to regulate B lymphocyte fate during humoral immune response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.