ArticlePloS one2011
Treatment of an intramammary bacterial infection with 25-hydroxyvitamin D(3).
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Vitamin D metabolites reshape bovine mammary epithelial responses relevant to mastitis through host-directed mechanisms.Frontiers in cellular and infection microbiology · 2026Article
- Calcium Metabolism, Immunity and Reproduction in Early Postpartum Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- 25(OH)vitamin D inflammatory and oxidative stress markers in healthy Holstein cows and cows with peri-partum diseases during the transition period.Scientific reports · 2025Article
- Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study.Cureus · 2025Article
- Enhancing Genomic Prediction Accuracy for Body Conformation Traits in Korean Holstein Cattle.Animals : an open access journal from MDPI · 2024Article
- Article
- Intramammary 25-hydroxyvitamin DJDS communications · 2023Article
- Stage of infection withFrontiers in veterinary science · 2023Article
- Bovine Immunity and Vitamin DMicroorganisms · 2022Review
- Effects of 1,25-Dihydroxyvitamin DFrontiers in veterinary science · 2022Article
- Vitamin DFrontiers in cellular and infection microbiology · 2022Article
- A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle.PLoS genetics · 2021Article
- Vitamin D signaling increases nitric oxide and antioxidant defenses of bovine monocytes.JDS communications · 2021Article
- Exogenous Vitamin DFrontiers in cellular and infection microbiology · 2021Article
- Determinants of vitamin D status in Kenyan calves.Scientific reports · 2020Article
- Vitamin D Metabolism and Profiling in Veterinary Species.Metabolites · 2020Review
- 1,25-hydroxyvitamin D3 decreases endoplasmic reticulum stress-induced inflammatory response in mammary epithelial cells.PloS one · 2020Article
- Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Review
- [Vitamin D level in children with bloodstream infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- 1,25-Dihydroxyvitamin D3 modulates calcium transport in goat mammary epithelial cells in a dose- and energy-dependent manner.Journal of animal science and biotechnology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deficiency of serum levels of 25-hydroxyvitamin D(3) has been correlated with increased risk of infectious diseases such as tuberculosis and influenza. A plausible reason for this association is that expression of genes encoding important antimicrobial proteins depends on concentrations of 1,25-dihydroxyvitamin D(3) produced by activated immune cells at sites of infection, and that synthesis of 1,25-dihydroxyvitamin D(3) is dependent on the availability of 25-hydroxyvitamin D(3). Thus, increasing the availability of 25(OH)D(3) for immune cell synthesis of 1,25-dihydroxyvitamin D(3) at sites of infection has been hypothesized to aid in clearance of the infection. This report details the treatment of an acute intramammary infection with infusion of 25-hydroxyvitamin D(3) to the site of infection. Ten lactating cows were infected with in one quarter of their mammary glands. Half of the animals were treated intramammary with 25-hydroxyvitamin D(3). The 25-hydroxyvitamin D(3) treated animal showed significantly lower bacterial counts in milk and showed reduced symptomatic affects of the mastitis. It is significant that treatment with 25-hydroxyvitamin D(3) reduced the severity of an acute bacterial infection. This finding suggested a significant non-antibiotic complimentary role for 25-hydroxyvitamin D(3) in the treatment of infections in compartments naturally low in 25-hydroxyvitamin D(3) such as the mammary gland and by extension, possibly upper respiratory tract infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.