ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2011
Prediction and prevention of schizophrenia: what has been achieved and where to go next?
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness.BMC psychiatry · 2014Trial
- Schizophrenia as a Disorder of Biological Barriers: A Narrative Review and Potential Interventions.International journal of molecular sciences · 2026Review
- Targeting Psychotic and Cognitive Dimensions in Clinical High Risk for Psychosis (CHR-P): A Narrative Review.Journal of clinical medicine · 2025Review
- Understanding Capacity to Treat First Episode Psychosis with a Hybrid Telemental Health Delivery Model: A Needs Assessment of Ohio Community Mental Health Centers.Administration and policy in mental health · 2025Article
- Attenuated mental symptoms in the general population: first data from the observational cross-sectional ATTENTION study in Greece.CNS spectrums · 2025Observational
- Sensitivity of the familial high-risk approach for the prediction of future psychosis: a total population study.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Clinical and Sociodemographic Correlations with Neurological Soft Signs in Hospitalized Patients with Schizophrenia: A Preliminary Longitudinal Study.Biomedicines · 2024Article
- The Actigraphy-Based Identification of Premorbid Latent Liability of Schizophrenia and Bipolar Disorder.Sensors (Basel, Switzerland) · 2023Article
- Mismatch negativity generation in subjects at risk for psychosis: source analysis is more sensitive than surface electrodes in risk prediction.Frontiers in psychiatry · 2023Article
- Neurobiologically Based Stratification of Recent-Onset Depression and Psychosis: Identification of Two Distinct Transdiagnostic Phenotypes.Biological psychiatry · 2022Article
- The positive dimension of schizotypy is associated with a reduced attenuation and precision of self-generated touch.Schizophrenia (Heidelberg, Germany) · 2022Article
- Multidimensional analysis of adult patients' care trajectories before a first diagnosis of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Nanotechnology Approaches for Enhanced CNS Drug Delivery in the Management of Schizophrenia.Advanced pharmaceutical bulletin · 2022Review
- Unrecognized schizophrenia spectrum and other mental disorders in youth disconnected from education and work-life.Frontiers in psychiatry · 2022Article
- Being Born in Winter-Spring and at Around the Time of an Influenza Pandemic Are Risk Factors for the Development of Schizophrenia: The Apna Study in Navarre, Spain.Journal of clinical medicine · 2021Article
- Attitudes towards Risk Prediction in a Help Seeking Population of Early Detection Centers for Mental Disorders-A Qualitative Approach.International journal of environmental research and public health · 2021Article
- Diagnosis of Schizophrenia Based on Deep Learning Using fMRI.Computational and mathematical methods in medicine · 2021Article
- Structural and functional imaging markers for susceptibility to psychosis.Molecular psychiatry · 2020Review
- A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis.Schizophrenia research · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
In modern medicine, vigorous efforts are being made in the prediction and prevention of diseases. Mental disorders are suitable candidates for the application of this program. The currently known neurobiological and psychosocial risk indicators for schizophrenia do not have a predictive power sufficient for selective prevention in asymptomatic patients at risk. However, once predictive basic and later pre-psychotic high risk symptoms of psychosis develop into the five-year initial prodrome, the impending outbreak of the disease can be predicted with high accuracy. Research findings suggest a differential strategy of indicated prevention with cognitive behavioral therapy in early initial prodromal states and low dosage atypical antipsychotics in late initial prodromal states. The most important future tasks are the improvement of the predictive power by risk enrichment and stratification, as well as the confirmation of the existing and the development of new prevention strategies, with a stronger focus on the etiology of the disorder. In addition, the prediction and prevention approach would benefit from the inclusion of risk symptoms in the DSM-5 criteria.
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Registered trials
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