ArticleFrontiers in neuroengineering2011
Engineered neuronal circuits: a new platform for studying the role of modular topology.
Article in Frontiers in neuroengineering, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Microscale dysfunction and mesoscale compensation in degenerating neuronal networks.Network neuroscience (Cambridge, Mass.) · 2026Article
- Role of connectivity anisotropies in the dynamics of cultured neuronal networks.PLoS computational biology · 2025Article
- Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Multiple neuron clusters on Micro-Electrode Arrays as an in vitro model of brain network.Scientific reports · 2023Article
- Rich dynamics and functional organization on topographically designed neuronal networksiScience · 2022Article
- Stimulus-Evoked Activity Modulation of In Vitro Engineered Cortical and Hippocampal Networks.Micromachines · 2022Article
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- Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings.Lab on a chip · 2022Article
- Brain-on-a-Chip: Characterizing the next generation of advancedAPL bioengineering · 2021Article
- Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.Micromachines · 2021Review
- Micropatterning of Substrates for the Culture of Cell Networks by Stencil-Assisted Additive Nanofabrication.Micromachines · 2021Article
- Thresholding Functional Connectivity Matrices to Recover the Topological Properties of Large-Scale Neuronal Networks.Frontiers in neuroscience · 2021Article
- Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease.NPJ Parkinson's disease · 2020Review
- Impact of Physical Obstacles on the Structural and Effective Connectivity ofFrontiers in computational neuroscience · 2020Article
- Article
- Article
- Propagation of temporal and rate signals in cultured multilayer networks.Nature communications · 2019Article
- Impact of modular organization on dynamical richness in cortical networks.Science advances · 2018Article
- Multichannel activity propagation across an engineered axon network.Journal of neural engineering · 2017Article
- Modularity Induced Gating and Delays in Neuronal Networks.PLoS computational biology · 2016Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Neuron-glia cultures serve as a valuable model system for exploring the bio-molecular activity of single cells. Since neurons in culture can be conveniently recorded with great fidelity from many sites simultaneously, it has long been suggested that uniform cultured neurons may also be used to investigate network-level mechanisms pertinent to information processing, activity propagation, memory, and learning. But how much of the functionality of neural circuits can be retained in vitro remains an open question. Recent studies utilizing patterned networks suggest that they provide a most useful platform to address fundamental questions in neuroscience. Here we review recent efforts in the realm of patterned networks' activity investigations. We give a brief overview of the patterning methods and experimental approaches commonly employed in the field, and summarize the main results reported in the literature. The general picture that emerges from these reports indicates that patterned networks with uniform connectivity do not exhibit unique activity patterns. Rather, their activity is very similar to that of unpatterned uniform networks. However, by breaking the connectivity homogeneity, using a modular architecture, it is possible to introduce pronounced topology-related gating and delay effects. These findings suggest that patterned cultured networks may serve as a new platform for studying the role of modularity in neuronal circuits.
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