ArticleAnnals of burns and fire disasters2010
Effect of antioxidants on the incidence of wound infection in burn patients.
Article in Annals of burns and fire disasters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- N-acetylcysteine for sepsis and systemic inflammatory response in adults.The Cochrane database of systematic reviews · 2012Pooled it
- Complex Hippocampal Response to Thermal Skin Injury and Protocols with Hyperbaric Oxygen Therapy andInternational journal of molecular sciences · 2024Article
- Therapeutic approach to emotional reactions accompanied with thermal skin injury - from basic to epidemiological research.World journal of psychiatry · 2024Article
- Development of propolis, hyaluronic acid, and vitamin K nano-emulsion for the treatment of second-degree burns in albino rats.BMC complementary medicine and therapies · 2024Article
- Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing.Mini reviews in medicinal chemistry · 2024Review
- Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing.Frontiers in bioengineering and biotechnology · 2024Article
- Simultaneous Administration of Hyperbaric Oxygen Therapy and Antioxidant Supplementation withMedicina (Kaunas, Lithuania) · 2023Article
- Neutrophils and the Systemic Inflammatory Response Syndrome (SIRS).International journal of molecular sciences · 2023Review
- Recovery of Polyphenolic Compounds and Vitamins from the Stinging Nettle Leaves: Thermal and Behavior and Biological Activity of Obtained Extracts.Molecules (Basel, Switzerland) · 2023Article
- Decreasing the Likelihood of Multiple Organ Dysfunction Syndrome in Burn Injury with Early Antioxidant Treatment.Antioxidants (Basel, Switzerland) · 2021Review
- Protective Effects of Melatonin against Severe Burn-Induced Distant Organ Injury: A Systematic Review and Meta-Analysis of Experimental Studies.Antioxidants (Basel, Switzerland) · 2020Review
- Seeds ofTheScientificWorldJournal · 2020Article
- Serum total antioxidant capacity prior to liver transplantation for hepatocellular carcinoma is associated with 1-year liver transplantation survival.The Journal of international medical research · 2018Observational
- Vitamin C supplementation in the critically ill: A systematic review and meta-analysis.SAGE open medicine · 2018Review
- Evaluation of phytochemicals, antioxidant and burn wound healing activities ofIranian journal of basic medical sciences · 2017Article
- Association between total antioxidant capacity and mortality in ischemic stroke patients.Annals of intensive care · 2016Article
- Association between Pre-Transplant Serum Malondialdehyde Levels and Survival One Year after Liver Transplantation for Hepatocellular Carcinoma.International journal of molecular sciences · 2016Article
- The role of antioxidant micronutrients in the rate of recovery of burn patients: a systematic review.Burns & trauma · 2016Review
- Effects of allopurinol on exercise-induced muscle damage: new therapeutic approaches?Cell stress & chaperones · 2015Review
- The effect of dietary intake of antioxidant micronutrients on burn wound healing: a study in a tertiary health institution in a developing country.Burns & trauma · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Thermal injury causes the destruction of the physical skin barrier that normally protects the body from invasion by micro-organisms and induces an immunocompromised state that predisposes burn patients to infection, sepsis, and multiple organ failure. Reactive oxygen species contribute to burn-mediated immune suppression, and as the use of antioxidants has a positive effect on immune function, this may reduce the incidence of wound infection and related complications in burn patients. Patients and methods. One hundred and eighty burn patients of either sex and different ages, suffering from burns of varying percentage, were involved in the study. They were allocated to six groups: A, B, C, D, E, and F, each of 30 patients. Groups B, C, D, E, and F were treated with antioxidants (vitamins E and C, zinc sulphate, allopurinol, melatonin, and N-acetylcysteine, respectively) while group A was treated without antioxidants, according to our hospital policy. Thirty healthy subjects (group G) were also involved in the study as a control group for comparison. In each group, serum malondialdehyde and serum glutathione levels, microbiological values, healing time, and the mortality rate were measured using standard methods. Results. Administering antioxidants to burn patients produced significant improvements in the parameters studied compared with burn patients not given antioxidants. Conclusion. The study clearly showed the beneficial effect of antioxidants in the treatment of burn patients, as evidenced by the reduced incidence of wound infection and the shortening of healing time, in addition to the lower mortality rate. It is therefore recommended to add antioxidants to the treatment list of burn patients.
Indexed as
Identifiers
21991225PMC3188280W1742579017What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.