ArticleApplied physics letters2011
Determination of binding kinetics using whispering gallery mode microcavities.
Article in Applied physics letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Light Concentration by Metal-Dielectric Micro-Resonators for SERS Sensing.Materials (Basel, Switzerland) · 2018Review
- Aptasensors Based on Whispering Gallery Mode Resonators.Biosensors · 2016Review
- Article
- Label free detection of 5'hydroxymethylcytosine within CpG islands using optical sensors.Biosensors & bioelectronics · 2015Article
- Real-time detection of lipid bilayer assembly and detergent-initiated solubilization using optical cavities.Applied physics letters · 2015Article
- Combining an optical resonance biosensor with enzyme activity kinetics to understand protein adsorption and denaturation.Biomaterials · 2015Article
- Hybrid integrated label-free chemical and biological sensors.Sensors (Basel, Switzerland) · 2014Review
- Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices.Nanophotonics (Berlin, Germany) · 2012Article
- Fabrication of silica ultra high quality factor microresonators.Journal of visualized experiments : JoVE · 2012Article
- Attaching biological probes to silica optical biosensors using silane coupling agents.Journal of visualized experiments : JoVE · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Silica optical microcavity sensors show great promise in the kinetic evaluation of binding pairs, fundamental in understanding biomolecular interactions. Here, we develop and demonstrate a novel platform, based on bioconjugated silica microsphere resonators, to study the binding kinetics of the biotin-streptavidin system. We characterize the optical performance, verify the covalent attachment of biotin to the surface, and perform streptavidin detection experiments. We perform preliminary kinetic analysis of the detection data which shows the potential of whispering gallery mode resonators in the determination of the dissociation constant of the binding pair, which is in good agreement with previously published values.
Identifiers
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Registered trials
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